BIOL 3333 1st Edition Lecture 20Paracentric Inversion: Centromere not involvedPericentric Inversion: Centromere is involvedCrossovers in inversion heterozygotes: generate meiotic products w/ gene duplications and deficiencies Crossovers within a paracentric inversion: will produce a centric and dicentric products that contain duplications and deficiencies *since crossover gametes are likely to be inviable: inversions are used by geneticists to suppress recombination b/w chromosomes in genetic stocks -these are “balancer chromosomes” and usually have multiple inversions*Population polymorphisms that do not lead to clinical problems: are often associated w/ constitutive heterochromatin *Remember that “position effects” may influence expression- can occur when a gene in a euchromatic region of the chromosome is transferred into or near a heterochromatic block Fragile X Syndrome- approx. 8% of males w/ mental retardation - 1/1250 male births- large testes, prominent jaw and head, large ears- detectable as visible chromosomal abnormality on cell culture *when grown in special medium, individuals w/ fragile X These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.chromosome will show narrowing or gap - fragile
View Full Document
Unlocking...