PSYC 222 1st Edition Lecture 17Outline of Last Lecture • Cannabis plant• cannabis preparations• marijuana history• marijuana history: U.S regulation• Marijuana tax act of 1937• after marijuana tax act• cannaboid chemicals• pharmacology• mechanism of action• cardiovascular/other effectsOutline of Current Lecture i. behavioral effectsii. cognitive effects: acuteiii. cognitive effects: chroniciv. medical uses of cannabisv. dronabinolvi. Medical use: state and federal actionCurrent Lecturei. Under controlled laboratory conditions. Marijuana cigarettes with higher THC content are preferred. More oral THC during periods of social interaction. Data indicate: the abuse potential of THC. Cannabis self administered is influenced by social factors. Subjectivee Effects: Euphoria "high" mellowness, hunger, and stimulation. Infrequent users may report negative effects such mild paranoia. Food Intake: increase total dailycalorie intake. Verbal Behavior: verbal exchanges decrease. Nonverbal social interactionsincrease.ii. Infrequent users: marijuana disrupts cognitive performance. Slowed cognitive processing. Impaired short term memory. Impairfed inhibitory control. Loss of sustained concetration or vigilance. Impaired visuospatial processing. Frequent users: Marijuana causes less dramatic effectsiii. Different to make definitive statements about effects on long term cognitive fuctioning. Studies have had divergent findings and interpretations. Current evidence suggests that after abstaining for more than a month, regular marijuana use produces few effect on cognition.iv. Medical uses declined before 1937 marijuana tax act because: New and better drugs were developed to treat most illnesses. Variability of product. Active ingredient insolublein water and this cannot be injected. Oral dose has delayed onset of action. 1970- present renewed interest in medical uses. Glaucoma and cancer treatment and related nausea.v. Dronabinol (brand name: Marinol). Oral THC preparation. Used as an atiemetic, 1985 FDA approved for cancer patients with nausea from chemotherapy. Used to stimulate appetite, 1993 FDA approved for sale to AIDS patients. vi. 1999 Institute of Medicine issued report that recommended use of marijuana when certain conditios are met. Failure of currently approved medications. Symptoms will be relieved by a rapid onset. Treatment is under medical supervision. Oversight strategy for dispensation. Legal medical use as of early 2014, 23 states and DC have legislation allowing medicial
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