BCOR 103 1st Edition Lecture 14 Outline of Last Lecture I. Sorting of ProteinsII. Uptake of Materials in the Plasma MembraneOutline of Current Lecture I. Cell Adhesion MoleculesII. Cell:Cell Junctions III. CollagenCurrent LectureThere are five important cell adhesion molecules. Selectins are the first, and they combine withcarbohydrates. This type of cell adhesion molecule is seen mostly in the cardiovascular system and does not form stable cell junctions. Integrins are used in cell to matrix interactions and occasionally by immune cells. Integrins do form stable cell junctions. The third molecule, called4 spanning, connects cells in the synapse and forms tight and gap junctions. Ig CAMs have 100+different varieties and are important in the immune system as well as neurons. Last is Cadherins. Cadherins require calcium to make a cell to cell adhesion. These are important in tissue differentiation and tissue development. Cell to Cell JunctionsName FunctionTight Junction Seals two cells together in an epithelial sheet to prevent leakageAdherens Junction Joins an actin bundle in one cell to an actin bundle in a different cellDesmosome Junction “Spot Weld” that anchors the tough IF’s in one cell to anotherGap Junction Cell to cell junction allowing the passage of small moleculesHemi desmosome Junction Anchors IF’s in a cell to the basal laminaThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.The most common protein in the mammalian body is collagen. Collagen is made up of a triple helix of alpha chains. It can be constructed of homopolymers or heteropolymers. There are three families of collagen: fibrillary collagens, sheet-formin collagens, and connecting
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