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IUPUI BIOL 101 - Genetics cont.

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BIOL K101 1st Edition Lecture 22Outline of Last Lecture Gregor Mendel and Mendel’s LawsSegregationIndependent AssortmentDefinitionsGeneLocusAlleleGenotypeHomozygousHeterozygousPhenotypeDominantRecessiveOne Trait Cross (Monohybrid Cross)Two Trait Cross (Dihybrid Cross)Genetic DisordersAutosomal Recessive DisordersAlbinismTay-SachsCystic FibrosisPhenylketonuria (PKU)Sickle Cell DiseaseOutline of Current Lecture Autosomal Dominant DisordersAchondroplasiaHuntington DiseaseExtended Mendelian GeneticsIncomplete Dominance Flower Color in SnapdragonCodominance (Multiple Allelic Traits)These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.ABO Blood TypesPleiotropyEpistasisPolygenetic InheritanceEnvironmental Impact on PhenotypePedigree AnalysisCurrent LectureAutosomal dominant human disorders: child will show the phenotype if he / she receives just 1allele from either parent (OR if a spontaneous mutation appears in the zygote) Some examples of autosomal dominant disorders are acondroplasia (dwarfism) and polydactyly (extra toes or extra fingers), 2% of people in the world carry the dominant trait for polydactyly. Complete Dominance is where one has two dominant alleles and no recessive ones. In this case, the traits do no blend and an intermediate phenotype is the results. Ex. White and Red arethe dominant alleles, pink is their product. Co-dominance is the presents of two dominant alleles that co exist together with a recessive allele. Ex: Blood type ABO. A and B are dominant, O is recessive. Pleiotropy is when two are more genes act additively to produce a phenotype or an outward result. Ex: height, hair. Epistasis is the presence of alleles at one place effect the expression of alleles at another place. Pedigree Analysis is a family tree that describes the interrelationship of parents and children across


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