PLPA 2010 1st Edition Lecture 12Outline of Last Lecture I. Plant Diseases III: TreesOutline of Current Lecture II. 2012 Fungal MeningitisIII.Human PathogensIV. Opportunists and pathogensV. ExamplesCurrent Lecture- 2012 Fungal Meningitiso - people who got an epidural steroid injectiono - the steroid medicine was contaminated with at least four different moldso - fungal meningitis causes fever, headache, stiff neck, nausea, and vomiting o “Worst Pharmaceutical disaster in decades” o New England Compounding Center source of the moldy injections was shut downin 2012o Exserohilum prefers to eat grass o It can grow in our spinal fluid, but it cant normally get it thereo - Its an opportunist- To be a human pathogen a fungus must…o - Grow at our body temperatureo - Get into uso - Fight or evade our immune systemo - Eat some part of us - Opportunists and pathogenso Exserohilum is an opportunisto Coccidioidomyscosiso - Most virulent of human fungal diseaseso - Aka valley fever - Grew on rodent droppings in SW US and Mexicoo - Doesn’t care about us, wants to live in soilo - Inhaled spores lead to diseaseo - Makes lots of spores in soils in the place where it livesThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.o - 60% of spores breathe the spores don’t get sicko - the rest have flu-like symptoms that may become severse but will usually be o - Only .5% develop potentially fatal form immune system in spinal fluid is not as strong  It cant get into us on its on  Not contagious Fungus spreads from lungs and affects other organisms - Examples: Cocci in jailo - High rates of valley fever at state prisions in CA central valleyo - More than a dozen deaths  Athlete’s Foot o Ringworm of the foot and nails was probably introduced to north America on the feet of soldiers returning from north Africa at the end of WW1  Ringworm Malasseziao - Most of us have this on our skin - Often involved in dandruff - Related to corn smut  Thrusho - Associated with changes in hormones or immunity Candida grows on the tongue and inside the moutho Hurts and smellso Not bread yeast its candida albicanso Cause of yeast infections in women and sometimes men o Not related to bred