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CORNELL HD 3700 - Approaching the brain, Thinking about the brain
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HD 3700 1st Edition Lecture 11Outline of Last Lecture I. Projectives and Self-ReportsII. Guide to the PrelimOutline of Current LectureI. Hamlet meets his fatherII. Approaching the brainIII. Thinking about the braina. Mind/body dualityb. How not to think about brain scansCurrent LectureI. Hamlet meets his father- Every time the king drinks at night everyone applauds- Horatio is saying you might temporarily lose your mind and fall—has an extraordinary ability to remain dispassionate while helping Hamlet- Trying to stop Hamlet from going—protecting him- Father and Hamlet both ramble- King Hamlet killed before confession—if you die before confession you go to purgatory where they burn the sins out of you then you can go to heaven- Hamlet says that he will revenge his father’s death- Watch Hamlet’s reaction to this traumatic event—seen his father’s ghost, learnedhis uncle murdered his father and seduced his mother- Hamlet’s response is to become cognitively disorganized and hypomanic o He starts realizing that he’s in a play (while memory still holds a seat in this distracted globe—theater)o Smile and be a villaino Hamlet calls the guard with a bird callo If there’s a jerk in Denmark then he’s a terrible person—redundant o I might act crazyII. Approaching the Brain- Species Specific Behavioro Here are the tasks of the brain for all animals Eating and drinking Fighting  Courting  Mating Caring for offspring- Brain areaso We understand the brain through animal models and through autopsies/ brain scanso Brain stem Medulla: regulates heart rate, blood pressure, rate of respiration- Basic, essential functions  The pons: switch for sleep and wakefulness Midbrain: controls body movement in fighting, sex and lowers pain when doing both. Carries our orders from the cortex, in lowermammals essentially calls the shots Cerebellum: takes sensory information from the nervous system but also communicates with the frontal lobes, so that physical motion (in fighting, sex, and everything else) can be precise and nuanced- When the cerebellum is damaged by a stroke, the patient’smotions become jerky and “gross” Basal ganglia: higher level of motor control that is involved with the control of slow movements and the large muscles of the body. - Involved with learning specific actions.o Thalamus and Hypothalamus Thalamus - Evolved to process more deeply and with more detail sensory information before sending it on the frontal lobes- Has two parts, one for each hemisphere The hypothalamus- Little Thalamus- Takes information from the sensory organs- Regulates the pituitary gland, which has a powerful influence on the body through the release of hormones- Involved with eating, drinking, sexual behavioro Limbic system Found on the border of the cerebral hemispheres and the brain stem, brings information from the cerebellum, routing it to the centers of the brain generating conscious thought, while also contributing to awareness, emotion, aggression, and memory The hippocampus: responsible for episodic memory, presumably directing its storage and retrieval. Also encodes spatial memories The amygdala: perhaps the center for “instinctive” aggression, it controls fight or flight in lower mammals and plays a role in our response to threats or trauma. - Patients with PTSD often show increased activation of the amygdalao Cerebral cortex Structure: two hemispheres connected by the corpus callosum. Each hemisphere has four areas or “lobes” Occipital lobe: this includes the visual cortex, which generates images from the information sent up through the brain stem, and the visual association cortex…where visual memories, categories, and focus are generated Temporal lobe: the primary auditory cortex and its association area Parietal lobe: includes the primary somato-sensory cortex and the somato-sensory association area The frontal lobes: where language, thought and judgment are generated. The prefrontal cortex “rewires” during adolescence, resulting in abstract thinking and higher orders of analysis and creativity. This region also controls fine movement. - Contemporary ways to image the braino Computed Tomography (CT) – images from narrow x-rays passed through the braino Magnetic Resonance Imaging (MRI) –a magnetic field around the brain is then agitated by radio waves; the scanner measures the rate by which themolecules return to their resting state, resulting in a high resolution imageo fMRI – a major improvement on the MRI because it detects levels of oxygen in the brain’s blood vessels.o Micro-electrodes can measure the electrical charges of individual neuronso Electroencephalogram (EEG) with sensors placed on a patient’s forehead, can measure seizure activity and stages of sleepo Positron Emission Tomography (PET) imaging brain activity by measuring positrons emitted by radioactive particles injected into the brain. Scientists can combine specific chemicals along with the radioactive material to observe specific brain activity. III. Thinking about the brain- Dualism – imagining the mind and body as separate entitieso The mind and the body are not separate—but we don’t experience our neurons firing—we have thoughto Where are you in your body?o Can you imagine yourself dead?o What do we tell children when someone they know has died?o Is there a spiritual realm “beyond” this one?o Are there ghosts, angels, demons?o Fundamentalist believers vs. “mainstream” believerso It is hard for us to think about consciousness as a rapid series of brain events- This contemporary belief/fantasy about the afterlife (“Ghost Whisperer”)o In this Hollywood genre, our spirits can be trapped on earth until we workout the psychological issues or conflicts left unresolved in our lives. A living person, with the ability to “speak to ghosts,” ends up playing psychotherapist, holding sessions with the departed and the ones they left behind.o Combination of psychotherapy—the wish to understand, the need to resolve personal issues—with the general spiritual belief that our spirits, separate from our bodies, continue after our death, heading to a reward or to punishment- Ways to misuse brain imagingo First: Use the imaging data to reverse mind/body dualism by using it to “prove” the “brain theory” Example: When writers write when scanned by an fMRI, certain parts of their brain light up-


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CORNELL HD 3700 - Approaching the brain, Thinking about the brain

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