BIOL 3333 1st Edition Lecture 14Outline of Last Lecture Cross outcomes between parentsPDNPDCurt SternMosaic pattern Mitotic RecombinationLinkage RelationshipsComplementationLOD Current LectureWhat was one of the first “laboratory” techniques used to map human genes?- Somatic Cell Hybridization What is Somatic Cell Hybridization?- an experimentally based segregation technique used to map genes to human chromosomes- cells from 2 different species are artificially fused together- human chromosomes will be randomly lost from the hybrid cells These notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.How does Somatic Cell Hybridization work?When are human chromosomes lost?- In hybrid cells What must occur for the gene product to be present?- the gene must be included in the hybrid cell’s genomeCan genetics occur without variation?- NoWhat is a gene or a point mutation?- an allelic change - or a change at a single locusWhat happens during a chromosomal mutation?- segments, entire chromosomes or sets of chromosomes CHANGE- there are aberrations due to changes in chromosome
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