IPHY 4440 1st Edition Lecture 13Outline of Last Lecture I. Nuclear Receptors and HP Axis Outline of Current Lecture II. ChemistryIII. Transport in bloodIV. Chemistry of POMCCurrent LectureI. Chemistry- Both single polypeptide chain- Both about 200 AA (common AA)- Both have -s-s- bonds 2 in GH 3 in PRL (2 in Gh – 3 in PRL)- GH and PRL: considerable overlap in AA sequences - GH and PRL may occur in oligomeric forms- GH monomer, GH dimer, GH trimer (Big GH), (Big big GH)II. Transport in blood - GH binding protein (Very similar to GH receptor) - Category 3: POMC peptides- ACTH (+) adrenal cortex- MSH (+) melanocytes- EOPs (endorphins) Endogenous Opioid peptides - “Endogenous morphine”- EOPs only in CNS: Enkephalins, Dynorphins - Different EOPs have different prohormonesPOMC EndorphinsProenkephalin enkephalinsProdynorphins dynorphins III. Chemistry of POMC- All peptides derived from same prohormone- Pro-opio-melano-cortin =POMCThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.- ACTH (39AA)- B-Lipotropin (91 AA)-a-MSH = 1-13AA of ACTH- g-Lipotropin= 1-58 AA of bLPH (in Pars intermedia- CLIP= Corticotropin-like-peptide Opoid structure: Morphine, Codeine, heroinNaloxone: potent opoid
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