PHARM 5509 1st EditionExam # 1 Study Guide Lectures: 1 - 10Lectures 1-2 (January 20)- History of toxicology- Know the people, their significant contributions, and the toxicological cases- Definitions- Know the definitions for understanding of terminology not for memorization- Branches of Toxicology- Know the branches and their focuses- Undesired (Toxic) Effects and Factors Influencing Toxicity- Know the various components of the spectrum of toxic effects, interaction of chemicals, and factors that influence toxicity- Dose-Response- Know definitions, relationships, curves, and evaluations- Measuring Toxicity and Evaluating Safety- Know necessary definitions and principles- Processes for Toxicity Development- Know necessary definitions and each of the 4 stepsLecture 3 (January 27)- Risk Assessment- Know necessary introductory concepts and definitions- Know each step of the 4 step process- Know content related to toxicity testingLecture 4 (January 27)- Medication Toxicities and the Health Care System- Describe how the current United States drug approval process contributes to medication toxicities- Identify current FDA mechanisms used to conduct post-marketing surveillance of medications- Apply various medication safety mechanisms to a specific patient case scenario- Explain the benefits and drawbacks of Spontaneous Reporting Systems - Assess a patient case for factors that may increase the risk for a patient to develop a medication toxicityLecture 5 (February 3)- Air Pollution- Know the necessary definitions for understanding content- Know the sources of air pollution- Know the 5 major air pollutants (carbon monoxide, sulfur oxide, hydrocarbons, particulates, nitrogen oxides)- Know the 2 types of smog (reducing and photochemical-oxidant)- Know the necessary indoor air pollution concepts (sick-building syndrome)Lecture 6 (February 3)- Occupational Toxicology- Define the term “occupational toxicology”- Make distinctions between the terms “dose” and “routes of exposure” in industrial setting- Understand occupational exposure limits (OELs) set by Federal Agencies and Professional organizations- Know the role of exposure monitoring in the industrial setting- Know the difference between “exposure monitoring” and “biological monitoring”Lectures 7-8 (February 10)- Industrial Solvents and Vapors- Know the major classifications of industrial solvents and the governmental agencies that regulate their use - Describe acute and chronic toxicities of industrial solvents and household chemicals- Identify major/target organs of toxicity for different solvents- Describe mechanisms of actions with known toxicokinetics and metabolism for each agent- Describe treatment options following intoxication with each agentLectures 9-10 (February 17)- Pesticides- Know major classifications of pesticides with the governmental agencies that regulate insecticide use - Describe major features and treatments options of chlorinated insecticides toxicity- Describe major features and treatments options of toxicities with organophosphate and carbamate insecticides - List two to three important herbicides, fungicides and rodenticides, and their major toxicities with treatment options- Know the source of Dioxin exposure - Identify major/target organ of toxicity for different insecticides- Describe mechanisms of actions with known toxicokinetics and metabolism for each insecticide- Describe treatment options following acute and chronic intoxication with each