BIOL 1114 1st Edition Lecture 9- How can a poisonous antidote save a person’s life?o What is caliber and how is it being used? Physostigmine Venesosa→ 1840 British missionary 1st observed the Efik people of western Africa using caliber bean extract to determine guilt or innocence in trials by ordeal Physostigmine: treatment foro Photophobiao Myasthenia graviso Glaucomao Alzheimer’s disease- Causes too many muscle contractions or muscle paralysis- How does it work?Physostigmine↑o Caliber inhibits acetylcholine→ (seizures) - How does normal neuromuscular junction work?o Nerve impulse: Action Potentialo What is the nature of an electrical signal? Shape allows certain molecules through When sodium gradients flow through axon it moves through the entire axon Potassium gradient= Na to close- How does signal get from one cell to the nexto Neurotransmitters signal presynaptic cell to synapse which releases acetylcholine into the membrane Diffusion spreads through molecules to molecules- Acetylcholine binds to receptors of postsynaptic cells causing it to contracto Too much causes too many contractions (= seizures)o However, an enzyme, acetylcholinesterase destroys acetylcholine Curare→ atropine regulate the destruction of acetylcholine→ used to save child’s life in beginning
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