TAMU BIOL 213 - Cancer (7 pages)

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Lecture number:
Lecture Note
Texas A&M University
Biol 213 - Molecular Cell Biol

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BIOL 213 1st Edition Lecture 25 Outline of Last Lecture I Eukaryotic cell cycle a Four phases II III IV V b Regulation was discovered by observing mitosis of Xenopus frog eggs Cyclin and Cdks control progression through the cell cycle a M cyclin binds to Cdk to create an M Cdk b The sharp decrease in levels of M cyclin after M phase is due to degradation of cyclin by proteasomes S Phase DNA replication G1 phase arrest due to DNA damage a Outline If DNA damage is detected p53 will be activated which will initiate transcription of the p21 gene The p21 protein a Cdk will bind to the active SCdk and inactivate it so that S phase cannot be initiated Apoptosis programmed cell death a It s mediated by an intracellular proteolytic cascade that cuts the cell up into nice little pieces b High stress to the p53 protein causes the p53 to induce apoptosis Outline of Current Lecture I The hallmarks of cancer II Discovery of oncogenes III Properties of cancer cells IV Activate motility pathways to invade tissues V Activate telomerase VI Genome instability VII Resist apoptosis VIII Kinds of genes that when they get mutations can cause cancer a Oncogenes b Tumor suppressor genes IX Recruit blood vessels a Angiogenesis X Cancer treatment a Traditional treatments These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute b Developing treatments Current Lecture I II The hallmarks of cancer a Sustained proliferation signaling i The pathways that initiate proliferation are on even if there s no proliferation signal b Evade growth suppressor signaling c Activate motility pathways to invade tissues d Activate telomerase i To keep the telomeres long so that the cell can keep dividing without worrying whether or not some of the chromosome will be lost e Genome instability f Resist apoptosis g Recruit blood vessels h Deregulated cell energetics i Tumor cells usually only go through glycolysis and not

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