WSU BIOLOGY 251 - Acid Base balance (4 pages)

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Acid Base balance

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Acid Base balance


topic 23-Acid Base balance

Lecture number:
Lecture Note
Washington State University
Biology 251 - Introductory Human Physiology

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BIO 251 1st Edition Lecture 23 Outline of Last Lecture I Input output of fluids ions a Balance concept b Types of input output II Fluid ion distribution in body a Fluid compartment within body b Ion distribution c Mvmt of water ions w I ECF d Regulation of fluid ion distrb III Regulation of ECF volume a Na balance b Mechanisms regulating Na in kidney c Control of Na reabsorption IV Regulation of ECF osmolarity a Purpose b How ECF effects ICF c Mechanisms of water reg Outline of Current Lecture I Background These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute a Acid b Base c Ph d Buffers II Chem buffer a Protein b Hb c phosphate III pulmonary ventilation IV kidney V acid base imbalances Current Lecture o o o o o Background Why regulate acid base balance Only a narrow pH range is compatible w life Effects of pH fluctuations Changes in muscles nerve excitability Acidosis too much H depresses CNS Alkalosis too little H causes overexcitability Change enzyme activities profoundly Influence K levels Acid chemistry review Acid is a hydrogen containing substance that dissociated in solution to produce Free H Anions neg charged ions Base chemistry review Base is substance that binds w free H removes it from solution pH review pH log 1 H Low pH high acid Every unit change in pH tenfold change in H b c it is a log scale Buffers review o o o o o o o o o o Mixture of several chemical compounds in solution that minimize pH changes when acid or base is added or removed from solution Chemical buffer systems are 1st line of defense against pH fluctuations Buffers respond within fractions of 2nd to changes in H Buffers pick up H rapidly but DO NOT eliminate from body not long term solutions HCO3 buffer Effective most important in body for buffering pH changes caused by anything other than CO2 generated acid b c HCO3 is produced from CO2 H HCO3 H2CO3 CO2 H20 Important buffering system

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