TAMU BIOL 319 - Final Exam Study Guide (17 pages)

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Final Exam Study Guide



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Final Exam Study Guide

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Pages:
17
Type:
Study Guide
School:
Texas A&M University
Course:
Biol 319 - Integrated Hum An/Phy I
Edition:
1

Unformatted text preview:

BIOL 319 1st Edition Final Exam Study Guide EXAM 4 REVIEW NOTES AND STUDY GUIDE Test 4 TOXINS INHIBITORS AND POISONS Protein that binds nicotine nicotinic receptor Realized that body makes endogenous ligand acetylcholine receptor binds nicotine Acetylcholine gated ion channels in brain linked to addictive behavior affects at much lower doses Acetylcholine gated ion channel agonist nicotine can act just like acetylcholine on skeletal muscle cell would need in huge amounts mimic of endogenous ligand Antagonist a chemical that binds a receptor but sits in key hole and doesn t open up gate inhibitor acetylcholine blocker can out compete endogenous acetylcholine that is released and block it from binding but does not activate anything itself blockers Ach curare blocker if gets into blood stream and extracellular fluid it can get into synapses in high concentrations and block activity of acetylcholine once released discovered by Indians found in plant gets into animals circulatory system and causes paralysis inhibits acetylcholine puff animal has muscle weakness and collapses ingesting it is not toxic because it gets broken up in GI tract anesthesiology creates relaxation in muscles makes them unconscious shuts down CNS but not too much go into deep sleep then use something to relax muscles at neuromuscular junction but not interfere with CNS SHOW ME A TOXIN AND I LL SHOW YOU A MEDICINE Botulinum too much would cause paralysis but at the right amount can be helpful Toxins water can be a toxin 11 13 Can help in small amounts hurt in large ones Per kg body weight is normalized for all people dependent upon body weight Antagonist competitor acetylcholine and curare compete for binding site antagonist binds and does nothing to open up channel but locks others from binding Curare paralyzes but does not mess with CNS Botulinum Toxin Mechanism Bacteria spores that do not need oxygen to be active thrives in no oxygen protein toxin considered to be most toxic substance on earth



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