GSU BIOL 2240 - Immunity (30 pages)

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Immunity



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Immunity

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Pages:
30
School:
Georgia State University
Course:
Biol 2240 - Intro to Human Physiology
Intro to Human Physiology Documents

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Immunity Stem cells Hemocytoblast Lymphoid stem cell Myeloid stem cell Committed cells Developmental pathway Myeloblast Promyelocyte Myeloblast Myeloblast Promyelocyte Promyelocyte Eosinophilic myelocyte Basophilic myelocyte Neutrophilic myelocyte Eosinophilic band cells Basophilic band cells Neutrophilic band cells Eosinophils Basophils a b Neutrophils c Granular leukocytes mast cells Monoblast Lymphoblast Promonocyte Prolymphocyte Monocytes Lymphocytes e d Agranular leukocytes Some become Some become dendritic cells 22 1 Innate Immunity non specific Decrease speed of or inhibits invasion 1st line of defense Physical barriers prevent entry or remove particles Skin tears saliva mucous membranes mucus 2nd line of defense Chemical mediators promote phagocytosis and inflammation Responses you are born with Adaptive immunity specific last line of defense Specificity of a particle Slower to react than innate system Responses you develop throughout life Innate Immunity protective barriers Protective chemicals inhibit or destroy microorganisms Skin acidity Lipids in sebum and dermcidin in sweat HCl and protein digesting enzymes of stomach mucosae Lysozyme of saliva tears mucus breast milk Respiratory system modifications Mucus coated hairs in the nose Cilia of respiratory tract sweep dust and bacteria laden mucus from respiratory passages Innate Immunity chemical mediators Phagocytes Inflammatory responses Antimicrobial proteins complement proteins Pyrogens Fever Innate Immunity chemical mediators Phagocytes Macrophages develop from monocytes to become the chief phagocytic cells Free macrophages wander through tissue spaces E g alveolar macrophages aka dust cells Fixed macrophages are permanent residents of some organs E g Kupffer cells liver and microglia brain Neutrophils Fist on site short lived hrs Dendritic cells not WBC Innate Immunity chemical mediators Inflammatory Response Basophils and mast cells Promote inflammation when activated by innate or adaptive system



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