UT Arlington NURS 3365 - Key Concepts kinetics and dynamics (2 pages)

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Key Concepts kinetics and dynamics



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Key Concepts kinetics and dynamics

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Pages:
2
School:
University of Texas at Arlington
Course:
Nurs 3365 - Pharmacology in Nursing Practice
Pharmacology in Nursing Practice Documents

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Key Concepts Kinetics and dynamics The big 3 Drug types prescription OTC herbal Clinical Trials Phase 1 2 3 and post marketing surveillance phase 4 Controlled Substances Schedules Pregnancy classifications Pharmacogenetics Genetic polymorphisms in different ethnic groups Drug names generic trade Drug formulations Kinetics versus dynamics 4 pharmacokinetic processes o Absorption Bioavailability extent of absorption Life span considerations age and health status Routes of administration and rate of absorption by site Effect of food on absorption Enteric coated Time release Solution suspension Ionization vs non ionized form Lipid solubility Effect of GI motility on absorption o Distribution Breast milk Placenta highways of drug transport Fat storage of drugs Blood brain barrier Protein binding Albumin Affinity Competition Conditions causing low albumin Hypo albuminemia Se albumin 3 0 o Metabolism o Goal of metabolism o Changing drug to metabolite o Active or inactive o Toxic or non toxic o Pro drugs o Need to be metabolized to active metabolite to work First pass effect gut circulation Effect on oral doses CYP450 inducers and inhibitors Pharmacogenetics Genetic polymorphisms Food and substances and drug metabolism Grapefruit Cranberry Juice o Excretion Renal Other body systems that can excrete drugs Clearance o Glomerular filtration o Tubular secretion o Tubular reabsorption Half life and steady state Loading dose Pharmacodynamics Drug action versus drug effect Receptors enzymes and miscellaneous Receptor specificity Receptor affinity Agonist or antagonist Effect Systemic or local Efficacy versus potency Tolerance Additive vs synergistic Therapeutic index Side effects versus adverse drug reactions allergies reactions and idiosyncratic reaction Toxicity Hepatotoxicity Ototoxicity Nephrotoxicity Adherence Additive and synergistic effects



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