VCU BIOL 209 - Pathogenesis (2 pages)

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ch 13

Lecture number:
Lecture Note
Virginia Commonwealth University
Biol 209 - Medical Microbiology

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BIOL 209 1st Edition Lecture 28 Outline of Last Lecture I Question Answer s II Lymphocytes III Inflammation IV Allergy V Adhesion VI Multiplication VII Exozymes Outline of Current Lecture I Question Answer s II Toxins III Immune Evasion Mechanisms Current Lecture I Question Answer s A The toxin produced by vibrio cholera acts on the intestinal epithelium is an example of an enterotoxin B Which is not an immune mechanism that directly targets extracellular pathogens CD8 T cells C What immune mechanisms would be effective against Listeria CD8 T cells II Toxins A Produced by infectious bacteria can alter normal host cell function or kill cells systematically or totally B Exozymes 1 Work outside the cell C Exotoxins 1 Particularly secreted to act on host cells generate endotoxins either single monomers or A B toxins a Kill cytotoxins b Alter function enterotoxins neurotoxins superantigens D Endotoxins 1 Released primarily upon pathogen lysis LPS 2 AB toxins are made of 2 subunits a B subunit that binds the host cell surface and helps transport the A subunit 3 Cytotoxins can also kill host cells by disrupting membranes These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute a Example hemolysins lyse erythrocytes they clear around colonies on blood agar plate it forms pores in host cells and reside in membranes 4 Enterotoxins affect cell function of intestinal epithelial cells a Cholera toxin secreted A B toxin activates ion pumps causing secretion out of intestinal cells Massive loss of water 5 Superantigens alter function of cell by stimulating and possibly killing T cells to produce cytokines a Provide cross bridge between MHC and T cell b Large proportion of T cells respond to superantigen c Induce massive production of cytokines Which can eventually kill T cells 6 Endotoxins break down products of gram negative pathogens a They are LPS related products b Acts on immune

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