VCU BIOL 209 - Immunopathology; allergy, sepsis, autoimmunity (2 pages)

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Immunopathology; allergy, sepsis, autoimmunity



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Immunopathology; allergy, sepsis, autoimmunity

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ch 16


Lecture number:
27
Pages:
2
Type:
Lecture Note
School:
Virginia Commonwealth University
Course:
Biol 209 - Medical Microbiology
Edition:
1
Unformatted text preview:

BIOL 209 1st Edition Lecture 27 Outline of Last Lecture I Question Answer s II ELISA Assay A Indirect Outline of Current Lecture I Question Answer s II Lymphocytes III Inflammation IV Allergy V Adhesion VI Multiplication VII Exozymes Current Lecture I Question Answer s A Salmonella typhi is associated with intestinal disease If S typhi got into a cut are you likely to get a wound infection No it doesn t have the tools to handle the innate immune defenses in that environment B Why do you think ingested pathogens typically have a high infectious dose The stomach is very acidic so they have to be able to survive that to get into the lower intestines II Lymphocytes A Recognize carbs nucleotides etc biomacromolecules B Don t recognize these structures on or in our cells because they self reactive T and B cells are deleted killed or inactivated during development 1 Molecular mimicry a Pathogens take advantage of this and resemble our structures in order to not be recognized Lymphocytes that recognize that mimicked structure s have been deleted b Examples diabetes type 1 and rheumatic fever Immunopathology associated with pathogen infection III Inflammation A A localized event These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 1 What if it wasn t local but systemic Inflammatory cytokines act on blood vessels throughout the body leading to loss of blood volume septic shock IV Allergy A Hypoimmune response even though substances aren t extremely harmful 1 Histamine alert system recruiting defenses to site of allergen 2 Systemic response anaphylaxis loss of blood pressure induced airway muscle contraction which is fatal 3 Allergen might be systemic when you re allergic to a drug penicillin venom food Table 13 4 factors that weaken host defenses and increase susceptibility to infection V Adhesion A Non specific adhesion of bacterial glycocalyx to host cell surface B Specific bacterial fimbrae binding to host cell surface VI Multiplication A Invasive and or toxigenic processes promote growth and expand infection B Bacteria use a variety of mechanisms to secrete virulence factors 1 Type III system can inject factors directly into host cells 2 Injected factors can change host cell cytoskeleton first enhancing adherence then leading to internalization a This apparatus is a virulence factor VII Exozymes A Some pathogens secrete hyaluronidase which breaks down hyaluronic acid a component of the extracellular matrix that forms part of the epithelial barrier


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