IUB BIOL-L 211 - Signal Transduction (4 pages)

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Signal Transduction

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Signal Transduction


Signal Transduction and Intro- protein detection

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Indiana University, Bloomington
Biol-L 211 - Molecular Biology
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BIOL L211 Lecture 34 Outline of Last Lecture I Antibiotics II Article III Protein Folding IV Protein Targeting Eukaryotes Outline of Current Lecture I Article II Signal Transduction III Protein detection Current Lecture Signal Transduction I Article A Does Turkey Make You Sleepy Scientific American B Tryptophan stands accused of causing post turkey sleepiness 1 An amino acid found in turkey 2 Used to make serotonin a Serotonin sleep regulating neurotransmitter 3 But competitive inhibition negates the effect of added tryptophan a Turkey has other amino acids in greater quantities than tryptophan C Carbohydrates may actually be the guilty party 1 Stimulate the release of insulin These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute 2 Insulin does not directly help tryptophan access the brain but it reduces competition by increasing the uptake of other amino acids into the muscles out of the blood II Signal Transduction A Method of intercellular communication 1 Transduction Cascade series of biochemical reactions that ultimately reaches a target and causes some type of cellular response series of 2 Signal Transduction Cascade some signal interacts with a cell surface receptor which activates intermediate molecules most commonly a phosphorylations 3 Typical cellular response triggered by the end of the signal transduction cascade is the activation or repression of a particular gene B Ligand 1 Ligand the signal that binds to the cell surface receptor 2 Can be hormone sugar protein etc 3 Source and target of the ligand changes signaling classification a Paracrine cells release signals into the extracellular medium and the signals act on local targets only signaling b Juxtacrine signals are tethered to the cell membrane rather than secreted these can only signal to cells in direct contact with the cell juxta next to can only signal to cells next to it c Endocrine cells

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