BU BIOL 502 - exam 3 notes (64 pages)

Previewing pages 1, 2, 3, 4, 30, 31, 32, 33, 34, 61, 62, 63, 64 of 64 page document View the full content.
View Full Document

exam 3 notes



Previewing pages 1, 2, 3, 4, 30, 31, 32, 33, 34, 61, 62, 63, 64 of actual document.

View the full content.
View Full Document
View Full Document

exam 3 notes

192 views


Pages:
64
School:
Binghamton University
Course:
Biol 502 - Biochem:Metabolic Aspects(DIS)

Unformatted text preview:

lecture 26 03 26 2012 Retrieval of RER enzymes that get into Golgi Why go backwards retrograde o RER proteins that contain a a sequence KDEL lys asp glu leu should stay in RER o Some RER enzymes accidentally escape to Golgi in COPII vesicles o These enzymes can be retrieved by KDEL receptors in COPI vesicles and returned to RER o KDEL sequence recognition key that makes it get retrieved back to the RER Can be altered to be forced to leave or go back to RER Lysosome acidic organelle for degradation break down things and recycling Energy of ATP hydrolysis is used to pump H into the lysosome acidify the lumen of lysosome o Can pump H out to make ATP Lysosomal enzyme targeting by Mannose 6 P targets enzyme to go to lysosome o 1 An enzyme destined for the lysosome is phosphorylated on a mannose sugar in the cis golgi Made in the RER o 2 Mannose 6 P receptors in trans golgi bind this protein and package it into vesicles o 3 Clathrin binds to the outside of these vesicles targeting them to become lysosomes o 4 Lysosome enzyme is released from the receptor as the lysosome matures o 5 Clathrin is released and the receptors are recycled to the golgi o 6 Some mannose 6 p that end up on the plasma membrane are retrieved and recycled Some fuse with the plasma membrane lecture 27 03 26 2012 Role of lysosome in phagocytosis 1 Particles are brought in by endocytosis into the cell 2 The vesicle formed inside the cell is called a phagosome 3 Lysosome fuse with phagosomes and transfer their hydrolytic enzymes inside creating a phagolysosome 4 The particle gets digested and nutrients pass into cytoplasm 5 The leftover non digestible material garbage is dumped out from residual bodies by exocytosis out of the cell Role of lysosome in autophagy get rid of dead organelles like mitochondria and chloroplast 1 An autophagic vesicle is formed by wrapping ER membrane around a dead mitochondria 2 Lysosome fuse with this to make an autophagolysosome 3 The lysosome transfer lytic enzymes into



View Full Document

Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view exam 3 notes and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view exam 3 notes and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?