UNT BIOL 3451 - Cancer and Regulation of the Cycle (6 pages)

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Cancer and Regulation of the Cycle



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Cancer and Regulation of the Cycle

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Finishing up cancer and the different ways in which it can be produced.


Lecture number:
24
Pages:
6
Type:
Lecture Note
School:
University of North Texas
Course:
Biol 3451 - Genetics
Edition:
1
Documents in this Packet

Unformatted text preview:

BIOL 3451 1st Edition Lecture 24 Outline of Last Lecture I 17 7 Gene Regulation in a Model Organism Transcription of the GAL genes of Yeast II 17 8 Posttranscriptional Gene Regulation Occurs at All the Steps from RNA Processing to Protein Modification III 17 9 RNA Silencing Controls Gene Expression in Several Ways IV 19 1 Cancer is a Genetic Disease That Arises at the Level of Somatic Cells V 19 2 Cancer Cells Contain Genetic Defects Affecting Genomic Stability DNA Repair and Chromatin Modifications Outline of Current Lecture I 19 2 Cancer Cells Contain Genetic Defects Affecting Genomic Stability DNA Repair and Chromatin Modifications II 19 3 Cancer Cells Contain Genetic Defects Affecting Cell Cycle Regulation III 19 4 Proto oncogenes and Tumor Suppressor Genes Are Altered in Cancer Cells IV 19 5 Cancer Cells Metastasize and Invade Other Tissues V 19 6 Predisposition to Some Cancers Can Be Inherited VI 19 7 Viruses Contribute to Cancer in Both Humans and Animals VII 19 8 Environmental Agents Contribute to Human Cancers Current Lecture I 19 2 Cancer Cells Contain Genetic Defects Affecting Genomic Stability DNA Repair and Chromatin Modifications o Cancers show chromosomal defects that we use to diagnose the type and stage of cancer Chronic myelogenous leukemia CML involving translocation of the C ABL gene on chromosome 9 into the BCR gene on chromosome 22 1 Figure 19 4 2 this structure known as the Philadelphia chromosome Xeroderma pigmentosum o Number of cancers caused by defects in genes that control DNA repair Xeroderma pigmentosum XP 1 Defective nucleotide excision repair leading to skin cancer Hereditary nonpolyposis colorectal cancer 1 Autosomal dominant syndrome These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your own notes not as a substitute II 2 Increased risk check a box off of colon ovary uterine and kidney cancers 3 8 genes implicated with four involved in DNA mismatch repair a Could be



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