UNT BIOL 3451 - Regulation of Gene Expression in Eukaryotes and Cancer (5 pages)

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Regulation of Gene Expression in Eukaryotes and Cancer



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Regulation of Gene Expression in Eukaryotes and Cancer

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Finish up gene regulation in eukaryotes and begin discussing cancer and cell cycle regulation. Begin discussing cancer and how it is regulated.


Lecture number:
23
Pages:
5
Type:
Lecture Note
School:
University of North Texas
Course:
Biol 3451 - Genetics
Edition:
1
Documents in this Packet

Unformatted text preview:

BIOL 3451 1st Edition Lecture 23 Outline of Last Lecture I 17 2 Programmed DNA Rearrangements Regulate Expression of a Small Number of Genes II 17 3 Eukaryotic Gene Expression Is Influenced by Chromatin Modifications III 17 4 Eukaryotic Transcription Initiation Is Regulated at Specific Cis Acting Sites IV 17 5 Eukaryotic Transcription Initiation Is Regulated by Transcription Factors That Bind to Cis Acting Sites V 17 6 Activators and Repressors Interact with General Transcription Factors at the Promoter VI 17 7 Gene Regulation in a Model Organism Transcription of the GAL genes of Yeast Outline of Current Lecture I 17 7 Gene Regulation in a Model Organism Transcription of the GAL genes of Yeast II 17 8 Posttranscriptional Gene Regulation Occurs at All the Steps from RNA Processing to Protein Modification III 17 9 RNA Silencing Controls Gene Expression in Several Ways IV 19 1 Cancer is a Genetic Disease That Arises at the Level of Somatic Cells V 19 2 Cancer Cells Contain Genetic Defects Affecting Genomic Stability DNA Repair and Chromatin Modifications Current Lecture I 17 7 Gene Regulation in a Model Organism Transcription of the GAL genes of Yeast o GAL1 and GAL10 controlled by central control region UASG UAS are functionally similar to enhancers in eukaryotes Four binding sites for Gal4 protein regulator Fig 17 11 Chromatin structure of UAS is constitutively open or DNase hypersensitive meaning that it is free of nucleosomes o Mutation in the regulator of GAL4 prevents activation Thus Gal80p is positive regulator controls transcription this way 1 Regulator must be present to turn on gene transcription II 17 8 Posttranscriptional Gene Regulation Occurs at All the Steps from RNA Processing to Protein Modification o Transcriptional control major type of regulation in eukaryotes posttranscriptional regulation plays just as much of a role or more These notes represent a detailed interpretation of the professor s lecture GradeBuddy is best used as a supplement to your



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