Lecture 13Slide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Slide 11Slide 12Slide 13Slide 14Slide 15Slide 16Slide 17Slide 18Slide 19Slide 20Slide 21Slide 22Slide 23Slide 24Slide 25Slide 26Slide 27Slide 28Slide 29Slide 30Slide 31Slide 32Slide 33Slide 34Slide 35Slide 36Slide 37Slide 38Slide 39Slide 40Slide 41Slide 42Slide 43Slide 44Slide 45Slide 46Slide 47Slide 48D3-isopentenyl pyrophosphateSlide 50Slide 51Slide 52Slide 53Slide 54Slide 55Slide 56Lecture 13•August 29, 2005•Lehninger (4th Edition), ChapterSkip the details on the metabolism of ketone bodiesMetabolic BiochemistryFATTY ACID SYNTHESISLNC Chapter 21LNC Fig. 21-1 the enzyme has threefunctional regions:- biotin carrier protein- biotin carboxylase- transcarboxylaseacetyl-CoA + CO2 ==> malonyl-CoALNC Fig. 21-4acyl carrier proteinLNC Fig. 21-2End of lecture 12August 26, 2005LNC Fig. 21-2LNC Fig. 21-2LNC Fig. 21-2 This group is transferred tothe other SH group to free the ACP-SH for the nextmalonyl groupLNC Fig. 21-3LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-5LNC Fig. 21-6 beginning of the second round:LNC Fig. 21-7LNC Fig. 21-13The normal product of fatty acid synthase is palmitate (16 carbons)elongation to stearate and longer chainstakes place in the endoplasmic reticulum (ER)desaturation to oleate also occurs in the ERpoly-unsaturatedthe shaded fatty acids are essential FAfor humansbut are made only in plantsDesaturation of fatty acids in vertebrates (in the smooth ER):requires molecular oxygenLNC Fig. 21-8Source of NADPHMalic enzyme is found in liver and other animal tissuesA similar enzyme is found in bundle sheath cells in C4 plantsLNC Fig. 21-9Source of NADPHSource of NADPHphotosynthesisfrom glucose to fatty acidsglucose pyruvate (in cytosol)pyruvate acetyl-CoA (in mitochondria)acetyl-CoA fatty acid (in cytosol) How does acetyl-CoA come out of mitochondria ?From glucose to fatty acidsmitochondriacytosolLNC Fig. 21-11Biosynthesis of cholesterolsteroidsisoprenoidsLNC pp. 799LNC Fig. 21-30LNC Fig. 21-32CH3 CH3 CH2 C CH CH2 CH2 C CH CH2nPolyisopreneLNC Fig. 21-36LNC Fig. 21-37aLNC Fig. 21-38LNC Fig. 21-40LNC Fig. 21-41LNC Fig. 21-423-isopentenyl pyrophosphateLNC Fig. 21-48 STEROID HORMONESVITAMIN DRUBBERDOLICHOLSQUINONEOTHER VITAMINSCAROTENOIDSPLANT HORMONES C |CH2 = C – CH2 – CH2 – O - P - O - PSkip several pages in chapter 21 (pp.784 - 798)read p. 785 about function/mechanism of aspirin, ibuprofen and other painkillers and related drugsEnd of lecture 13August 29,
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