ABIO 598F Virology Dr. Wm. JacksonSyllabus Spring 2001Instructor InformationInstructor:William H. Jackson, Ph.D.Office:SBDG 111BOffice Hours:By AppointmentTelephone:641-3601Email:[email protected] InformationLecture:MW: 1:00-2:15Text:Basic Virology, by Wagner andHewletSupplies:Scantron Sheets and disketteAdditionalInformation:http://www.usca.sc.edu/biogeo/faculty/Jackson/Jackson.htmlCourse Description: Virology is a three credit hour course for biology majors thatcovers the basic principles of virology. Topics covered will include viral diseases, virus-cell interactions, and patterns of viral replication. The course will primarily cover virusesdirectly involved in human disease.Course Objectives: This course will introduce the student to the underlying principles ofvirology. On completion of this course, the student will be expected to1. Describe the replication strategies of RNA and DNA viruses2. Describe the pathogenesis of viral diseases in humans3. Describe strategies to prevent and combat viral diseases4. Conduct a literature search and prepare a written review of a given virus familyAttendance Policy: Students are expected to adhere to the University attendance policyas stated in the Student Handbook. In this regard, the instructor may impose a penalty forabsences in excess of 25% of regularly scheduled class meetings by assigning an "F" forthe course. Absences, neither excused nor unexcused, absolve the student from meetingclass assignments.Disability Statement: If you have a physical, psychological, and/or learning disabilitywhich might affect your performance in this class, please contact the Office of DisabilityServices, 126A B&E, (803) 641-3609, as soon as possible. The Disability Services Officewill determine appropriate accommodations based on medical documentation.Methods of Presentation and Evaluation: Information will be presented throughlectures, class discussion, and laboratory exercises using appropriate visual aids andlaboratory equipment. Student evaluation will be based on two examinations, weeklyquizzes, and a written oral report. Weekly quizzes are short tests designed to place theprevious week's material in focus. They will be given at the beginning of lecture and willbe timed. There will be no make up for weekly quizzes. For the weights given eachcomponent, see the table below.ABIO 598F Virology Dr. Wm. JacksonSyllabus Spring 2001Description Percentage CommentsMidterm Exam 30% Comprehensive exam covering the first half of thesemesterFinal Exam 30% Comprehensive exam covering the second half of thesemesterWeekly quizzes 20% Quizzes will be taken on Monday's of each week andwill cover the material of the previous weekReview 20% Written review of a virus familyYou will be expected to endorse the USCA HONOR PLEDGE on every assignment: 'Onmy honor as a University of South Carolina Aiken student, I have neither given norreceived any unauthorized aid on this assignment/examination. To the best of myknowledge, I am not in violation of academic honesty'.Written Review. Twenty percent of the final grade will be from a semester researchproject. Each student will be provided with the name of a virus to research. The studentwill conduct a literature search and prepare a written report on their virus. This report willprovide information about the viruses' morphology, molecular biology, pathology,epidemiology, and host range. It should also include a discussion of the means of viralreplication. The report should be double-spaced and include appropriate visual aids and abibliography. The paper should have at least five references, only one of which can be aweb site. If more web sites are required, additional journal/text references must beincluded (2 for every web site). To accompany the written report, the student will preparea MS PowerPoint presentation of the virus information. The written component of thereport is due on 3.2.01 (Midterm) and will count 75% of the total. The PowerPointpresentation is due on 3.30.01 and should be turned in as a file on your diskette. It willcount 25% of the total. The review requirements will be discussed on the first day ofclass and virus names will be handed out at that time.Format, Written:IntroductionClassification and MorphologyMolecular Biology and Replication StrategyHost(s) and EpidemiologyDiagnosis and PathologyTreatment and PreventionFormat, Presentation:The PowerPoint presentation should follow the same format as the written component.However, when preparing a presentation, individual slides should convey informationwithout so much detail that the intent of the slide is lost.ABIO 598F Virology Dr. Wm. JacksonSyllabus Spring 2001TENTATIVE LECTURE SCHEDULEWEEK DATE TOPIC CHAPTERVIROLOGY AND VIRAL DISEASE1 1.17.01 Introduction to Virology 12 1.22.011.24.01An Overview of Viral Replication and PathogenesisViral Disease Within Populations233 1.29.01 Patterns of Human Viral Diseases 4BASIC PROPERTIES OF VIRUSES AND VIRUS-CELL INTERACTIONS1.31.01 Virus Structure and Classification 54 2.5.012.7.01The Beginning and End of the Viral Replication CycleThe Beginning and End of the Viral Replication Cycle665 2.12.012.14.01Host Immune Response to Viral InfectionsHost Immune Response to Viral Infections776 2.19.012.21.01Strategies to Protect Against and Combat Viral InfectionsStrategies to Protect Against and Combat Viral Infections88WORKING WITH VIRUSES7 2.26.012.28.01Transcription and Translation in ProkaryotesMidterm Exam131 - 88 3.12.01 Transcription and Translation in Eukaryotes 13REPLICATION PATTERNS OF SPECIFIC VIRUSES3.14.01 Replication of Positive-Sense RNA Viruses 159 3.19.013.21.01Replication of Positive-Sense RNA VirusesReplication Strategies of RNA Viruses Requiring RNA151610 3.26.013.28.01Replication Strategies of RNA Viruses Requiring RNAReplication Strategies of Small and Medium-Sized RNA Viruses161711 4.2.014.4.01Replication Strategies of Small and Medium-Sized RNA VirusesReplication of Nuclear-Replicating Eukaryotic DNA Viruses171812 4.9.014.11.01Replication of Nuclear-Replicating Eukaryotic DNA VirusesReplication of Cytoplasmic DNA Viruses181913 4.16.014.18.01Replication of Cytoplasmic DNA VirusesRetroviruses192014 4.23.014.25.01RetrovirusesHepadnaviruses202115 4.30.01 Hepadnaviruses 21Final5.4.01 Final Exam at 2:00 PM in SBDG 10713 -