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Use of clonidine in children with autism spectrum disorders



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Brain Development 30 2008 454 460 www elsevier com locate braindev Original article Use of clonidine in children with autism spectrum disorders Xue Ming a Emily Gordon b Ning Kang c George C Wagner d a Department of Neuroscience and Pediatrics UMDNJ New Jersey Medical School 90 Bergen Street Doctor s O ce Center 8100 Newark NJ 07103 USA b Class of 2009 UMDNJ New Jersey Medical School Newark NJ USA c Department of Biostatistics School of Public Health University of California Los Angeles CA USA d Department of Psychology Rutgers University New Brunswick NJ USA Received 20 July 2007 received in revised form 18 November 2007 accepted 14 December 2007 Abstract Children with autism spectrum disorders ASD often exhibit sleep and behavioral disorders Treatment of sleep disorders can be di cult in these children Clonidine an a2 adrenergic receptor agonist has been shown to be e ective in reducing impulsivity inattention and hyperactivity as well as in serving as a sedative for medial procedures An open labeled retrospective study of clonidine in treatment of insomnia and or hyperactivity inattention mood disorder and aggressive behaviors was conducted using parent reports of sleep initiation and maintenance as well as behaviors prior and during clonidine treatment Clonidine was e ective in reducing sleep initiation latency and night awakening to a less degree in improving attention de cits hyperactivity mood instability and aggressiveness in this cohort of 19 children with ASD The side e ects were largely tolerable Further evaluation with placebocontrolled double blind clinical trial of clonidine use in ASD will provide more insight into the clinical e cacy and safety of the medicine in ASD 2007 Elsevier B V All rights reserved Keywords Autism spectrum disorders Clonidine Sleep disorders Attention de cit hyperactivity disorders Aggression Mood instability 1 Introduction Children with autism spectrum disorders ASD suffer from medical and psychiatric conditions including



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