Week #Lecture Date Topics Reading1 1 Tuesday, 1/10/06 Introduction Chapter 1, 2, page 1-59, 2 Thursday, 1/12 Protein Structure Chapter 3, page 59-1002 3 Tuesday, 1/17 Protein Function4 Thursday, 1/19 Protein Analysis3 5 Tuesday, 1/24 DNA and RNA Structures Chapter 4, page 101-1316 Thursday, 1/26 Gene Structure and Transcription (Midterm I, Feb. 3, Fri. 5-6:50pm,4 7 Tuesday, 1/31 Translation covers lectures #1-7)8 Thursday, 2/2 DNA Replication I Chapter 4, page 131-1455 9 Tuesday, 2/7 DNA Replication II Chapter 23, page 961-97010 Thursday , 2/9 Recombinant DNA Technology I Chapter 9, page 351-4036 11 Tuesday, 2/14 Recombinant DNA Technology II12 Thursday 2/16 Recombinant DNA Technology III7 13 Tuesday, 2/21 Genome Structure I Chapter 10, page 405-44914 Thursday 2/23 Genome Structure II (Midterm II, March 3, Fri. 5-6:50pm,8 15 Tuesday, 2/28 Transcriptional Regulation Icovers lectures #8-15), Chapter 1116 Thursday 3/2 Transcriptional Regulation II Chapter 11, page 447-4919 17 Tuesday, 3/7 Post-transcriptional Regulation I Chapter 12, page 493-53118 Thursday 3/9 Post-transcriptional Regulation II10 19 Tuesday, 3/14 Post-transcriptional Regulation III20 Thursday 3/16 Review11 Tuesday, 3/21/06 6:30PM - 9:30PM, Location TBA Final Exam, covers allLS3-2 (W2006) SyllabusLS3-2, W06 C. Lin,Life Science 3 (LS3-2)Introduction to Molecular Biology Winter 2006 (January 10 – March 21)Instructor: Chentao Lin,Professor of Molecular, Cell & Developmental BiologyOffice: 3317 Life Science Building (LSB),Phone: 310-206-9576, email: [email protected]: http://www.mcdb.ucla.edu/Research/Lin/Lectures Tuesday and Thursday, 2:00 am - 3:15 pm, LaKretz 110Office hours: Tuesday and Thursday, LSB 33173:30-5:00pm, Tuesday and Thursday, or walk in at any timeTextbook: “Molecular Cell Biology” (2004) by Lodish, et. al.Supplemented by handoutsCourse Web site: http://www.lsic.ucla.edu/classes/winter06/Lab & discussion Sections: Discussion sections (wk 1, 3, 5, 6, 9 ) and Lab (wk 2, 4, 6, 8, 10)will be lead by your TAs and Dr. Gaston Pfluegl ([email protected], 794-4113). See the“LS3 lab manual” for details of the lab sections.Teaching Assistants: Mariam Aghajan, [email protected] Seema Bhopole, [email protected] Chen, [email protected] Cheng, [email protected] France, [email protected] Georgia, [email protected] Green, [email protected] Lee, [email protected]: Please address all administrative problems to Life Science CoreCurriculum Office: LSB2305, Phone: 825-6614Exams & Grading: Laboratory: 100pts 20%Midterm I (February 3) 100pts 20%Midterm II (March 3) 100pts 20%Final (March 21) 200pts 40%LS3-2, W05 C. Lin,Life Science 3 (LS3-2) Honor’s sectionIntroduction to Molecular Biology Winter 2006 (January 10 – March 21)Instructor: Professor Chentao Lin,Office: 3317 Life Science Building (LSB),Phone: 310-206-9576, email: [email protected]: http://www.mcdb.ucla.edu/Research/Lin/Purpose: The honor’s section is designed to help student understand how molecular biologyknowledge and methods are used to answer basic questions in life sciences.Study Materials The students participating in the LS3 honor’s section are required to readthe assigned research articles (posted online). They are expected to understandthe questions addressed in individual research articles, the methods used to solvethe problems, the conclusions derived from the experiments, and additionalquestions remain to be further studied.Discussion sections: The students are required to attend discussion sections once every week(time to be determined), which is to help them understand the research articles.Research Proposal: The students are required to write a research proposal (minimum 4-5 page,single spaced, or 8-10 page, double spaced). The proposal needs to be turned in by Friday,March 24, 2006. The research proposal will include the following sections:1. Introduction: it describes the current knowledge of the specific research area. For example,what is cryptochrome, what are the function of Arabidopsis cryptochromes, what do we knowabout how Arabidopsis cryptochromes function. What is the specific question that you proposeto study. For example, what residues of in Arabidopsis CRY2 are phosphorylated, how doesCRY2 regulate CO ubiquitination and degradation, etc.2. Specific aim: the specific question(s) will be addressed and why the question is important orinteresting from scientific point of view.3. Methods: specific method(s) to address the questions, why the proposed method(s) isappropriate, what pitfalls it may have, and what alternative method you may need.Grade: pass/no