TRANSLATION - PROTEIN SYNTHESIS Genetic code: p 234, table 11.1, handoutTriplet, degenerate (redundant), unambiguouswobble Key participants:m RNA, r RNA, t RNAProkaryotic translation:Coupled transcription and translationt RNA and Amino acid activation: figs 12.8, 12.11, handoutStructure, unusual basesAmino acyl t RNA synthetases and their functionRibosome: figs 12.12, 12.13, handoutRole of r RNA - structure, 16S r RNA and initiationRole of ribosomeProcess of Translation:Initiation: figs 12.14, 12.15, handoutStart codon (AUG), Shine-Dalgarno sequencef-met t RNA, initiation factorsElongation: figs 12.16, 12.17, handout Amino acyl t RNA binding: EF-Tu, TsTranspeptidation - peptidyl transferaseTranslocationTermination: fig 12.18, handoutNon-sense codon, release factorsProtein folding:ChaperonesWhat are molecular chaperones? Why are these referred to as “Heat shock proteins”?(fig 12.19)Dna K, Dna J. Grp E, Gro ES, Gro ELProtein synthesis an energy intensive processInhibitorsProtein splicing: fig
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