CU-Boulder CHEM 6321 - Isomerism with Rigid Molecular Graphs (36 pages)

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Isomerism with Rigid Molecular Graphs



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Isomerism with Rigid Molecular Graphs

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Lecture Notes


Pages:
36
School:
University of Colorado at Boulder
Course:
Chem 6321 - Special Topics in Physical Organic Chemistry

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Isomerism with Rigid Molecular Graphs Pasteur 1848 Kekule 1858 vant Hoff and Le Bel 1874 Cayley 1874 Chiral Non congruent mirror images Kelvin in 1904 The Molecular Graph 1821 1895 England 1842 graduated Trinity College as senior wrangler 1849 became a lawyer 1863 became chair of math at Cambridge where he died happy but poor 966 papers Invented the concept of two kinds of geometry Euclean and Topological Invented modern matrix algebra Invented group theory Invented the molecular graph Isomerism with Rigid Molecular Graphs Pasteur 1848 Kekule 1858 vant Hoff and Le Bel 1874 Cayley 1874 Chiral Non congruent mirror images Kelvin in 1904 Lord Kelvin s Definition of Chirality Kheir is Greek for Hand In 1904 Lord Kelvin delivered his famous Baltimore Lectures on Molecular Dynamics and the Wave Theory of Light in which he stated I call any geometric figure or group of points chiral and say it has chirality if its image in a plane mirror ideally realized cannot be brought to coincide with itself Chemists did not start using the term until the 1960s Eliel s first edition of Streochemistry of Carbon Compounds does not contain the term according to John C Leffingwell Chirality and Odour Perception http www leffingwell com chirality chirality htm Senior wrangler e g Cayley was the student who scored highest on the Cambridge math Tripos exam Kelven was only Second Wrangler Most interesting quote There is nothing new to be discovered in physics now All that remains is more and more precise measurement Address to the British Association for the advancement of Science in 1900 Isomerism in Non Rigid Molecular Graphs Euclidean Molecular Rigidity Topological Non Homeotopic Molecular Graph Some Interesting Examples of Euclidean Isomerism Br Br Br OH Br OH Br Br OH Homomers Classic problems with unambiguous solutions chiral chiral chiral OH OH OH OH OH chiral Br Br chiral Cl Cl chiral Br Br Br Br Conformers chiral Br Cl Gray Area OH Enantiomers chiral Br OH chiral Homomers chiral Br



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