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Nonsimultaneous Chains and Dominos in Kidney Paired Donation



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Nonsimultaneous Chains and Dominos in Kidney Paired Donation Revisited Running Title NEAD Chains and DPD Chains in Kidney Paired Donation American Journal of Transplantation 11 5 May 2011 pp984 994 Itai Ashlagia Duncan S Gilchristb Alvin E Rothb and Michael A Reesc d e a Department of Operations Management Sloan School of Management Massachusetts Institute of Technology 50 Memorial Drive Cambridge MA 02142 b Department of Economics and Harvard Business School Harvard University 25 Harvard Way Boston MA 02163 c Department of Urology University of Toledo Medical Center 3000 Arlington Avenue Mailstop 1091 Toledo OH 43614 d e Alliance for Paired Donation Inc 3661 Briarfield Boulevard Maumee OH 43531 Corresponding Author Office 419 383 3961 FAX 419 383 3344 email michael rees2 utoledo edu Key Words Paired Kidney Exchange Simulation Models ABO incompatibility Allosensitization Transplantation Policy Regional Sharing Word Count 3 955 words 1 Abbreviations NEAD nonsimultaneous extended altruistic donor DPD domino paired donation KPD kidney paired donation NDD non directed donor APD Alliance for Paired Donation PRA panel reactive antibodies UNOS United Network for Organ Sharing CIC R D computer identified compatible recipient donor NDPD k non simultaneous long DPDs of length k NEAD k non simultaneous long NEAD chain of length k HLA human leukocyte antigen 2 Abstract Since 2008 kidney exchange in America has grown in part from the incorporation of nondirected donors in transplant chains rather than simple exchanges It is controversial whether these chains should be performed simultaneously domino paired donation DPD or nonsimultaneously nonsimultaneous extended altruistic donor chains NEAD NEAD chains create bridge donors whose incompatible recipients receive kidneys before the bridge donor donates and so risk reneging by bridge donors but offer the opportunity to create more transplants by overcoming logistical barriers inherent in simultaneous chains Gentry et al simulated



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