VCU PHTX 441 - Inflammation (12 pages)

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Inflammation



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Inflammation

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Lecture Notes


Pages:
12
School:
Virginia Commonwealth University
Course:
Phtx 441 - Pharmacology Dental Hygiene
Pharmacology Dental Hygiene Documents

Unformatted text preview:

Inflammation The body s natural response to injury Characteristics Dilation increase in diameter fenestration increase in permeability of the capillaries Edema swelling redness Local rise in temperature Pain sensitivity to pain Influx of leukocytes esp Polymorphonuclear leukocytes PMNs and macrophages Increased tenfold drainage into lymphatic system PMN infiltration into damaged tissue BLOOD CELLS Type Function Cells ml blood Red Blood Cells 5 X 1012 Erythrocytes transport O2 CO2 White Blood Cells leukocytes Granulocytes PMNs neutrophils phagocytose bacteria 5 X 109 Eosinophils allergic response 2 X 108 Basophils release histamine serotonin 4 X 107 Monocytes become macrophages 4 X 108 Lymphocytes B cells make antibodies 2 X 109 T cells cell mediated immunity 1 X 109 Platelets blood clotting 3 X 1011 1 Effectors of Inflammation Interleukins signaling peptides IL 1 released by macrophages other cells after injury Activates phospholipase prostaglandin synthesis Synthesis of IL 8 ELAM IL 8 chemotactic factor attracts PMNs PMN adhesion Prostaglandins from arachidonic acid vasodilation Sensitizes nerve endings to pain Leukotrienes chemotactic factors from arachidonic acid Histamines permeability of capillary entothelial cells 2 PMN infiltration into damaged tissue IL 1 Histamines endothelial cells IL 8 leukotrienes PMNs Overview of the Inflammatory Response ELAM syn Injury IL1 syn IL8 syn Phospholipase Acitvity Histamine Release IL interleukin syn synthesis PMN Adhesion to Endothelial Cells Attract PMNs Leukotriene syn Prostaglandin Dilation syn Fenestration ELAM entothelial leukocyte adhesion molecule PMNs polymorphonuclear leukocytes Edema PMN Infiltration 3 Linkage of inflammation to other systems Complement system activated by antibody antigen complexes activation of proteases that can damage normal tissue Clotting fibrinolytic system intimately linked to late stages of inflammation as part of the healing process Resolution of inflammation The normal scenario



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