UCSD BILD 1 - Lecture (21 pages)

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Lecture



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Lecture

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Lecture Notes


Pages:
21
School:
University of California, San Diego
Course:
Bild 1 - The Cell
The Cell Documents

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Clicker Q5 1 Which biological molecule is this A Phospholipid B Triacylglycerol fat C Carbohydrate D Amino acid Fig 5 18 Pep de bond Amino acids are connected via peptide bond Polypeptide synthesis N C direction a Pep de bond b Amino end N terminus Carboxyl end C terminus Fig 5 21g How a protein assumes its correct shape shape function Folding of a polypeptide 1 Primary 2 Secondary 3 Tertiary Some proteins consists of two or more polypeptides Quaternary structure Hemoglobin Collagen Fig 5 21a Primary Structure 1 5 H3N Amino end 10 Amino acid subunits 15 20 25 Fig 5 21c Secondary Structure pleated sheet Examples of amino acid subunits helix Hydrogen bonds between O and H atoms in the backbone of the polypep de Tertiary structure interactions between the Rgroups Hydrophobic interac ons and van der Waals interac ons Fig 5 21f Hydrogen bond Disul de bridge Ionic bond Quaternary Structure associa on of several polypep des Fig 5 21g Polypep de chain Chains Iron Heme Collagen Chains Hemoglobin Clicker Q5 2 Which of the amino acids below would most likely reside in the membrane anchoring domain of a membrane embedded protein A Phenylalanine B Serine Phenyl alanine C Lysine Serine Lysine NUCLEIC ACIDS store and transmit hereditary informati Two types 1 DEOXYRIBONUCLEIC ACID DNA The permanent blueprint that passes genetic information from one cell to the next and from generation to generation 2 RIBONUCLEIC ACID RNA Genes are transcribed into MESSENGER RNA mRNA that are temporary blueprints for the construction of proteins DNA RNA PROTEIN polypep de DNA Transcrip on 1 Synthesis of mRNA in the nucleus mRNA NUCLEUS CYTOPLASM mRNA 2 Movement of mRNA into cytoplasm via nuclear pore Transla on Ribosome 3 Synthesis of protein Polypep de Fig 5 26 Amino acids The structure of a nucleo de three major components Ribose Nucleic acid is a chain of nucleotides connected by phosphodiester bonds phosphodiester bond linking between the 3 carbon of one nucleo de and the 5 carbon of the other



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