UMD CMSC 838T - A combined algorfthm for genome wide prediction of protein function (4 pages)

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A combined algorfthm for genome wide prediction of protein function



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A combined algorfthm for genome wide prediction of protein function

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Lecture Notes


Pages:
4
School:
University of Maryland, College Park
Course:
Cmsc 838t - Advanced Topics in Programming Languages
Advanced Topics in Programming Languages Documents

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durtcr for the synthesis ofa dass ofcellwall lipids uniqueto pathogenic mycobacteria I Bid Chm 272 16741 16745 1997 9 Mathur M Kolattukudy P E Moledar cloning and sequencingof the gene for mycoccmsic acid s p t h a s c a novel Fdttyacid elongating multifunctional enzyme from Mycobncrcrium rubmulosir n r bovis Bacillus Calmme Guenn 1 B i d Chem 267 19388 19395 1992 K Sirakova T D Rogaa L M Koiaitukudy P E Targeted replacementofthe mymaorie acid synthasegene in Mymbanm umb w i s BCG prcduca a mutant that lack mycosides IO ad A pmc vntrAud sci USA93 4787 4792 199s tionally related yeast proteins Links between characterized and uncharacterized proteins allow a general function to be assigned to more than half of the 2 557 previously uncharacterized yeast proteins Examples of functional links are given for a protein family of previously unknown function a protein whose human homologues are implicated in colon cancer and the yeast prion al sup35 The historical method of finding the function of a protein involvesextensivegenetic and biochemical analyses unless the amino acid sequence of the protein resembles another whose function is known With complete genome sequences and total mRNA expression patterns new strategies become available We show that the general biochemical functions of proteins can be inferred by associatingproteins on the basis ofproperties other than 15 Pierce C H Dubos R I DiifercntialchancteristicsinvinoandinvivoofsevenlsubnninsofBCG the similaritybetween their amino acid sequences These properties 11 Morphotogiccharaneriaio in vim and in vivo Am RN Tubnc Pulm Dis 74 667 642 1956 associate proteins that are functionally related which we define as 16 Middlebrook G Dubos R J Piera C Vidcncc and morphological characteristicsof proteins that participate in a common structural complex metamammalian tubercle bacilli 1 Ecp M d 86 175 183 1947 pathway biological process or closelyrelatedphysiological 1 7 W n u a t e r D L h d y P E S y n c h a i r o f m y o c e



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