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Determining the Optimal Sampling Interval of the Exhaled Nitric Oxide Profile



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Author Determining the Optimal Sampling Interval of the Exhaled Nitric Oxide Profile Richard W Taylor Biomedical Engineering Richard Taylor started working in Professor George s lab in Spring 2008 which he describes as the opportunity to work on an innovative approach to diagnosing asthma on a team bringing their unique talents and experiences together to solve a common problem He found it particularly rewarding to be able to contribute practical results to a problem that is so widespread and poorly understood Upon graduating from UCI Richard hopes to make a career of research pursuing a Ph D and eventually working and teaching at a research institution Abstract N itric oxide NO is present in exhaled breath after being produced by cells throughout the lungs NO is affiliated with inflammation including pulmonary inflammatory diseases such as asthma The widespread and growing presence of asthma highlights the need for improved diagnosis and treatment methodologies the affiliation between NO and inflammation gives rise to the possibility that NO measurements could be used as a clinical tool in the diagnosis and treatment of inflammatory pulmonary disease As one step toward this goal this study sought to discover the most reliable interval of the exhaled NO signal for analysis Exhaled NO measurements of 51 patients aged 7 16 years with mild to moderate asthma were collected at the Breathmobile operated by the Children s Hospital of Orange County Exhaled volume was measured relative to each subject s airway volume and collected at flows of 50 100 and 200 ml s The volume of exhaled breath was normalized relative to the volume of the airway tree The data shows that the clearest and most reliable interval of the exhaled breath on which to measure nitric oxide is from four to six airway volumes This information will enable more reliable use of exhaled nitric oxide ultimately enabling more accurate asthma diagnosis and treatment decisions for the pediatric population Faculty



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