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Gamma Ray Imaging of Small Animals



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Gamma Ray Imaging of Small Animals Using Position Sensitive Photomultiplier Tubes A thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Science in Physics from the College of William and Mary in Virginia By Julie Cella Williamsburg Virginia April 16th 2004 Acknowledgments I would like to thank the generous support and guidance offered by my advisor Dr Robert Welsh of the Physics Department and Dr Eric Bradley and Dr Margaret Saha of the Biology Department I would also like to thank the kind advice and assistance offered by Jianguo Qian of Applied Science and Kevin Smith William and Mary 03 In addition I would like to acknowledge our collaborators at Jefferson Lab Stan Majewski Vladimir Popov Mark F Smith Andrew G Weisenberger and Randy Wojcik This research would not be possible without the support of NIH Department of Energy National Science Foundation The Jeffress Trust and in particular The HHMI Science Education Program for their support of my summer research additional semester grants and travel grant 2 Abstract This thesis is an interdisciplinary investigation of small animals consisting of two parts First a comparison of NaI Tl and CsI Tl pixilated scintillating crystals will be presented based on results of resolution tests performed using 5 diameter Hamamatsu 5800 PSPMTs Second application of the gamma ray detectors will be assessed using a biological model The biological model chosen to analyze is the efficacy of potassium iodide as a blocking agent to the uptake of radioiodine by the thyroid The blocking dose of potassium iodide is tested and the implications discussed 3 Table of Contents 1 Introduction 5 2 SPECT Demands and Resolution Tests 7 2a CsI Tl Crystal 8 2b NaI Tl Crystal 10 2c Conclusion of Resolution Tests 12 3 Thyroid Blocking with Potassium Iodide as a Biological Model 12 3a Reasons to Study KI blocking 13 3b Summary of Previous Literature on Efficacy of KI Blocking 15 4 KI Blocking Study 18 4a Data



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