LEHIGH BIOS 328 - TCR 2 (16 pages)

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TCR 2



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TCR 2

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Pages:
16
School:
Lehigh University
Course:
Bios 328 - Immunology
Immunology Documents

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IMMUNOLOGY Bios 328 a textbook based study of immunology Spring 2003 http www lehigh edu sk08 Courses Bios328 mainpage htm TCR seen here in a ternary complex TCR seen here in a ternary complex TCR s come in two flavors TCR s like Ig s have immense diversity TCR s like Ig s have immense diversity 5461 40 41 42 43 44 45 46 5461 40 41 42 43 44 45 46 5461 22 0 22 1 22 2 22 3 22 4 22 5 22 6 5461 20 22 24 26 28 210 212 5461 CD3 two heterodimers one homodimer specifically a variant is obtained by alternative splicing of the template CD3 All of the CD3 proteins have a negative charge aspartic acid in the transmembrane helix Interacts with positive charge in the TCR transmembrane component All CD3 proteins have ITAM immunoreceptor tyrosine activation motifs recognized by tyrosine kinases Members of the larger MIRR multi chain immune recognition receptor class CD3 gamma delta and epsilon are members of the immunoglobulin superfamily Each chain has an immunoglobulin domain a transmembrane component a cytoplasmic tail approximately 44 to 55 amino acids long 90 of chains with zeta are homodimers Zeta and eta have 9 aa external domains a transmembrane component and a cytoplasmic tail of 113 aa in zeta and 155 aa in eta the two variants are transcripts of a common gene the transcripts are alternatively spliced CD 4 55 kDa monomeric glycoprotein Four immunoglobulin domains CD8 A heterodimer usually sometimes One immunoglobulin domain small glycoproteins 30 38 kDa S Sa transmembrane component a long cytoplasmic domain with three serine residues transmembrane component cytoplasmic tail 25 27 residues CD4 and MHC II The length of immunoglobulin folds in CD4 is equal to the two immunoglobulin folds in a TCR plus the peptide binding domain in MHC II and the proximal immunoglobulin fold in MHC II Thus these components can associate Specifically the most distal immunoglobulin fold of CD4 associates with the 2 immunoglobulin fold of MHC II CD4 and MHC II Other molecules Lots of them and



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