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A New Device for Mechanical Testing of Blood Vessels at Cryogenic Temperatures



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Experimental Mechanics 2007 47 337 346 DOI 10 1007 s11340 007 9038 8 A New Device for Mechanical Testing of Blood Vessels at Cryogenic Temperatures J L Jimenez Rios Y Rabin Received 22 November 2006 Accepted 23 January 2007 Published online 27 February 2007 Society for Experimental Mechanics 2007 Abstract As part of an ongoing program to study the thermo mechanical effects associated with cryopreservation via vitrification vitreous in Latin means glassy the current study focuses on the development of a new device for mechanical testing of blood vessels at cryogenic temperatures This device is demonstrated on a bovine carotid artery model permeated with the cryoprotectant cocktail VS55 and a reference solution of 7 05M DMSO below glass transition Results are also presented for crystallized specimens in the absence of cryoprotectants Results indicate that the elastic modulus of a specimen with no cryoprotectant at about 140 C 8 6 and 15 5 C below the glass transition temperature of 7 05M DMSO and VS55 respectively is 1038 8 25 2 MPa which is 8 and 3 higher than that of a vitrified specimen permeated with 7 05M DMSO and VS55 respectively The elastic modulus of a crystallized material at 50 C is lower by 20 lower from that at 140 C Keywords Blood vessels Vitrification Cryopreservation Mechanical testing VS55 DMSO Introduction Vitrification vitro in Latin means glass has been presented as a promising alternative to conventional cryopreservation whereby ice crystallization known to be the cornerstone of cryoinjury is suppressed 1 2 Vitrification is achieved J L Jimenez Rios Y Rabin Biothermal Technology Laboratory Department of Mechanical Engineering Carnegie Mellon University Pittsburgh PA 15213 USA e mail rabin cmu edu by means of rapid cooling of a highly viscous material i e cryoprotectant when the cooling time scale is much shorter than the typical time scale for crystallization causing the cryoprotectant molecules to be trapped in an arrested state Vitrification can



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