UNC-Chapel Hill GNET 624 - LECTURE NOTES (11 pages)

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LECTURE NOTES



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LECTURE NOTES

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Lecture Notes


Pages:
11
School:
University of North Carolina at Chapel Hill
Course:
Gnet 624 - Developmental Genetics

Unformatted text preview:

Basic Organization of the neural tube Formation and patterning of the nervous system I Neural Induction and Neurulation specification of neural fate and formation of the neural tube II Neural Patterning patterning of neural progenitors along the dorsoventral and anteroposterior axis III Neurogenesis differentiation of neural progenitors into postmitotic neurons and glia IV Understanding neural patterning in the context of neurogenesis Neural stem cell lineage diagram illustrating the generation of different subtypes of neurons and glia Interneuron s responsible for the modification coordination between sensory and motor neurons Sensory neurons conduct impulses from receptors to the brain and spinal cord such as vision sound touch pain etc Motor neurons conduct impulses from the brain and spinal cord to effectors such as muscles and glands Many different types of neurons are found in the neural tube Basic Organization of the neural tube Neuronal differentiation in the caudal neural tube Roof plate dl1 Progenitors dividing in ventricular zone dl2 dl3 dl4 dl5 Postmitotic neurons in mantle layer dl6 V0 V1 Sensory neurons conduct impulses from receptors to the brain and spinal cord such as vision sound touch pain etc Interneuron s responsible for the modification coordination between sensory and motor neurons V2 MN V3 Floor plate Motor neurons conduct impulses from the brain and spinal cord to effectors such as muscles and glands 1 Neural stem cell lineage diagram illustrating the generation of different subtypes of neurons and glia Basic Organization of the neural tube Neural stem cell lineage diagram illustrating the generation of different subtypes of neurons and glia Glial differentiation in the caudal neural tube At about E13 5 rat and E11 5 mouse Oligodendrocyte precursors arise ventrally in a region that also generates neuronal precursors Cells migrate dorsally and ventrally before differentiation into oligodendrocyes Astrocyte differentiation is first detected



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