EVERGREEN INS 2008 - Alive! The race to create life from scratch

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Alive! The race to create life from scratch12 February 2005 NewScientist.com news service Bob Holmes YOU might think Norman Packard is playing God. Or you might see him as the ultimate entrepreneur. As founder and CEO of Venice-based company ProtoLife, Packard is one of the leaders of an ambitious project that has in its sights the lofty goal of life itself. His team is attempting what no one else has done before: to create a new form of living being from non-living chemicals in the lab. Breathing the spark of life into inanimate matter was once regarded as a divine prerogative. But now several serious and well-funded research groups are working hard on doing it themselves. If one of them succeeds, the world will have met alien life just as surely as if we had encountered it on Mars or Europa. That first alien meeting will help scientists get a better handle on what life really is, how it began, what it means to be alive and even whether there are degrees of "aliveness". "We want to demonstrate what the heck life is by constructing it," says Packard's business partner and colleague Steen Rasmussen, a physicist at Los Alamos National Laboratory in New Mexico. "If we do that, we're going to have a very big party. The first team that does it is going to get the Nobel prize." Although the experiments are still in the earliest stages, some people, especially those with strong religious beliefs, feel uneasy at the thought of scientists taking on the role of creators. Others worry about safety - what if a synthetic life form escaped from the lab? How do we control the use of such technology? Finding a way to address these worries will have benefits beyond helping scientists answer the basic questions of life. The practical pay-offs of creations like Rasmussen's could be enormous. Synthetic life could be used to build living technologies: bespoke creatures that produce clean fuels or help heal injured bodies. The potential of synthetic organisms far outstrips what genetic engineering can accomplish today with conventional organisms such as bacteria. "The potential returns are very, very large - comparable to just about anything since the advent of technology," says Packard. And there is no doubt that there is big money to be made too. Only a few research groups have explicitly set themselves the goal of making a synthetic life form (see "Race for the ultimate prize" - bottom). Most are adapting bits and pieces from existing organisms. ProtoLife's plans are the most ambitious and radical of all. They focus on Rasmussen's brainchild, which he has nicknamed the Los Alamos Bug. Still but a gleam in its creator's eye, the Bug will be built up from first principles, using chemicals largely foreign to existing creatures. "You somehow have to forget everything you know about life," says Rasmussen. "What we have is the simplest we could dream up." To achieve this radical simplicity, Rasmussen and his colleagues had to begin with the most basic of questions: what is the least something must do to qualify as being alive? Biologists and philosophers struggled to answer that question for decades (New Scientist, 13 June 1998, p 38). However, most now agree that one key difference - perhaps the only one - between life and non-life is Darwinian evolution. For something to be alive, it has to be capable of leaving behind offspring whose characteristics can be refined by natural selection. That requires some sort of molecule to carry HOME | NEWS | EXPLORE BY SUBJECT | LAST WORD | SUBSCRIBE | SEARCH | ARCHIVE | RSS | JOBS Click to Print Enlarge image The Only Load Balancer In The World That Is Designed For ultra-low power consumption, L4-7 functionality,... www.kemptechnologies.com The Only Load Balancer In The World That Is Designed For ultra-low power consumption, L4-7 functionality,... www.kemptechnologies.com The Only Load Balancer In The World That Is Designed For ultra-low power consumption, L4-7 functionality,... www.kemptechnologies.com Ads by PheedoPage 1 of 5Alive! The race to create life from scratch - fundamentals - 12 February 2005 - Print Artic...10/4/2007http://www.newscientist.com/article.ns?id=mg18524861.100&print=truehereditary information, as well as some sort of process - elementary metabolism - for natural selection to act upon. Some kind of container is also needed to bind these two components together long enough for selection to do its work. Containment, heredity, metabolism; that's it in a nutshell. Put those together in the simplest way possible, and you've got the Los Alamos Bug. But every step is completely different from what we're used to (see graphic - the four stages shown are described further in "The Los Alamos Bug" - below). Take containment, for example. Terrestrial life is always water-based, essentially a watery gel of molecules enclosed within an oily membrane. Modern cells move nutrients across this membrane with the help of an array of different proteins embedded in the membrane. The Los Alamos Bug, however, is completely different. For a start it is oil-based, little more than a droplet of fatty acids. "Instead of having a bag with all the good stuff inside, think of having a piece of chewing gum," says Rasmussen. "Then you stick the metabolic molecules and genetic molecules into the chewing gum, so they are attached on the surface or sitting inside the chewing gum." The bare necessities The container is the easy part. The next step - heredity - is where most efforts to create synthetic life get bogged down. The challenge is to create a molecule complex enough to carry useful genetic information, which can also replicate. In modern organisms DNA has a whole army of enzymes to help it replicate its genetic information - far too complicated a process for the Bug. Instead, Rasmussen plans to use a molecule called peptide nucleic acid, or PNA. It uses the same "letters" of genetic code as DNA, but has two forms, one soluble only in fat, the other also attracted to water. Rasmussen hopes to put PNA's dual nature to use in a rudimentary form of replication (see Graphic). The Bug's metabolism has also been pared down to the minimum. The researchers plan to "feed" it with chemicals that can be converted into fatty acids. If enough are produced, the droplet will grow and divide into two. A similar metabolic process turns PNA precursors into functional PNA. Although most of the design is still on the drawing board or in the earliest stages of experimentation, the


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