UW-Madison CHEM 346 - Catalytic asymmetric synthesis

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1 Information Department, P.O. Box 50005, SE-104 05 Stockholm, Sweden Phone: +46 8 673 95 00, Fax: +46 8 15 56 70, E-mail: [email protected], Web site: www.kva.se __________________________________________________________ Advanced information on the Nobel Prize in Chemistry 2001 Catalytic asymmetric synthesis Three researchers share this years’ Nobel Prize in Chemistry; Dr William S. Knowles, who has been working at Monsanto Company, St Louis, USA; Professor Ryoji Noyori, Nagoya University, Chikusa, Nagoya, Japan and Professor K. Barry Sharpless, The Scripps Research Institute, La Jolla, California, USA. The Royal Swedish Academy of Sciences rewards the three chemists for: ”their development of catalytic asymmetric synthesis”. Knowles and Noyori receive half the Prize for: “ their work on chirally catalysed hydrogenation reactions” and Sharpless is rewarded with the other half of the Prize for: ”his work on chirally catalyzed oxidation reactions”. The discoveries made by the three organic chemists have had a very great impact on academic research and the development of new drugs and materials and are used in many industrial syntheses of drugs and other biologically active compounds. Below is given a background and description of their discoveries. Chiral molecules This year’s Nobel Prize in Chemistry concerns the development of chiral transition metal catalysts for stereoselective hydrogenations and oxidations - two important classes of synthetic reactions. Through the Laureates’ work a myriad of useful chiral compounds have become accessible. Many of the compounds associated with living organisms are chiral, for example DNA, enzymes, antibodies and hormones. Therefore enantiomers of compounds may have distinctly different biological activity . Thus the enantiomers of limonene, both formed naturally, smell differently - one of the enantiomers (S)-limonene smells of lemons, while the mirror image compound (R)-limonene smells of oranges (Fig. 1). Figure 1: (R)-Limonene smells of oranges and (S)-limonene smells of lemons.2 We distinguish between these enantiomers because our nasal receptors are also made up of chiral molecules that recognise the difference. Insects use chiral chemical messengers (pheromones) as sex attractants and chemists have discovered that one of the enantiomers of the insect pheromone, olean, attracts male fruit flies, while its mirror image operates on the female of the species. Thus biology is very sensitive to chirality and the activity of drugs also depends on which enantiomer is used. Most drugs consist of chiral molecules. And since a drug must match the receptor in the cell, it is often only one of the enantiomers that is of interest. In certain cases the other enantiomer may be harmful. In the early 1960s, the drug thalidomide was prescribed to alleviate morning sickness in pregnant woman. Tragically, the drug also caused deformities in the limbs of children born by these women. It seems that one enantiomer of thalidomide was beneficial while the other caused the birth defects. This theory is being questioned, partly because the two enantiomers of thalidomide easily can interconvert in the body. Pharmaceutical companies nowadays have to make sure that both enantiomers of a drug are tested for their biological activity and toxicity before they are marketed. Obviously, there is a strong demand for to the pure enantiomers. Catalytic asymmetric syntheses Industrial companies are concerned about disposing of unwanted compounds and also about the inefficiency and costs involved in the chemical processes. Therefore there is a strong demand for efficient methods for asymmetric syntheses. Thus finding new methods of asymmetric synthesis has in the past 20 or 30 years become a key activity for organic chemists. Ideally, a chiral agent should behave as a catalyst with enzyme-like selectivity. A small amount of material containing the chiral information could generate a large amount of a chiral product. Research has been intensive to develop methods for catalytic asymmetric synthesis i.e. catalytic methods to prepare one of the enantiomers in preference to the other. In a catalytic asymmetric reaction, a chiral catalyst is used to produce large quantities of an optically active compound from a precursor that may be chiral or achiral. In recent years, synthetic chemists have developed numerous catalytic asymmetric syntheses that convert prochiral substrates into chiral products with high enantioselectivity. These developments have had an enormous impact on academic and industral organic syntheses. One single chiral catalyst molecule can direct the stereoselection of millions of chiral product molecules. Such reactions are thus highly productive and economical, and, when applicable, they make the waste resulting from racemate resolution obsolete. It is researchers in this field who are rewarded with this year’s Nobel Prize in Chemistry.3 Knowles´pioneer work In the early sixties it was not known whether catalytic asymmetric hydrogenation was feasible. A breakthrough came in 1968 when Knowles at Monsanto Company, St. Louis showed that a chiral transition metal based catalyst could transfer chirality to a non-chiral substrate resulting in chiral product with one of the enantiomers in excess.1 Two developments in the mid-sixties offered an attractive approach to making such a catalyst. The first was the discovery by Osborn and Wilkinson of the rhodium complex, [(PPh3)3RhCl], as a soluble hydrogenation catalyst for unhindered olefins. Homogeneous catalysts had been reported earlier, but this was the first one that compared in rates with the well-known heterogeneous counterparts.2 The other development was the discovery of methods for preparing optically active phosphines by Horner3 and by Mislow4. Knowles’ basic strategy was to replace triphenylphosphine in Osborn and Wilkinson’s catalyst with the enantiomer of a known chiral phosphine and hydrogenate a prochiral olefine. Knowles soon verified the validity of this thinking by using the known non-racemic methylpropylphenylphosphine (69% of ee of (-)-methylpropylphenylphosphine) and reducing substituted styrenes (Fig. 2). Figure 2: Knowles’s catalytic asymmetric hydrogenation of α-phenylacrylic acid using a rhodium catalyst containing (-)-methylpropylphenylphosphine (69% ee) gave (+)- hydratropic acid in 15% ee. A modest enantiomeric excess (ee) was obtained but it was too


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