Chance and Statistical Significance in Protein and DNA Sequence AnalysisSamuel Karlin; Volker BrendelScience, New Series, Vol. 257, No. 5066. (Jul. 3, 1992), pp. 39-49.Stable URL:http://links.jstor.org/sici?sici=0036-8075%2819920703%293%3A257%3A5066%3C39%3ACASSIP%3E2.0.CO%3B2-MScience is currently published by American Association for the Advancement of Science.Your use of the JSTOR archive indicates your acceptance of JSTOR's Terms and Conditions of Use, available athttp://www.jstor.org/about/terms.html. JSTOR's Terms and Conditions of Use provides, in part, that unless you have obtainedprior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content inthe JSTOR archive only for your personal, non-commercial use.Please contact the publisher regarding any further use of this work. Publisher contact information may be obtained athttp://www.jstor.org/journals/aaas.html.Each copy of any part of a JSTOR transmission must contain the same copyright notice that appears on the screen or printedpage of such transmission.The JSTOR Archive is a trusted digital repository providing for long-term preservation and access to leading academicjournals and scholarly literature from around the world. The Archive is supported by libraries, scholarly societies, publishers,and foundations. It is an initiative of JSTOR, a not-for-profit organization with a mission to help the scholarly community takeadvantage of advances in technology. For more information regarding JSTOR, please contact [email protected]://www.jstor.orgMon Mar 24 14:25:45 2008You have printed the following article:Chance and Statistical Significance in Protein and DNA Sequence AnalysisSamuel Karlin; Volker BrendelScience, New Series, Vol. 257, No. 5066. (Jul. 3, 1992), pp. 39-49.Stable URL:http://links.jstor.org/sici?sici=0036-8075%2819920703%293%3A257%3A5066%3C39%3ACASSIP%3E2.0.CO%3B2-MThis article references the following linked citations. If you are trying to access articles from anoff-campus location, you may be required to first logon via your library web site to access JSTOR. Pleasevisit your library's website or contact a librarian to learn about options for remote access to JSTOR.References and Notes3Association of Charge Clusters with Functional Domains of Cellular Transcription FactorsVolker Brendel; Samuel KarlinProceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 15.(Aug. 1, 1989), pp. 5698-5702.Stable URL:http://links.jstor.org/sici?sici=0027-8424%2819890801%2986%3A15%3C5698%3AAOCCWF%3E2.0.CO%3B2-B5Phase Transitions in Sequence Matches and Nucleic Acid StructureMichael S. Waterman; Louis Gordon; Richard ArratiaProceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 5.(Mar. 1, 1987), pp. 1239-1243.Stable URL:http://links.jstor.org/sici?sici=0027-8424%2819870301%2984%3A5%3C1239%3APTISMA%3E2.0.CO%3B2-G5Profile Analysis: Detection of Distantly Related ProteinsMichael Gribskov; Andrew D. McLachlan; David EisenbergProceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 13.(Jul. 1, 1987), pp. 4355-4358.Stable URL:http://links.jstor.org/sici?sici=0027-8424%2819870701%2984%3A13%3C4355%3APADODR%3E2.0.CO%3B2-Mhttp://www.jstor.orgLINKED CITATIONS- Page 1 of 8 -NOTE: The reference numbering from the original has been maintained in this citation list.5Automatic Generation of Primary Sequence Patterns from Sets of Related Protein SequencesRandall F. Smith; Temple F. SmithProceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 1.(Jan., 1990), pp. 118-122.Stable URL:http://links.jstor.org/sici?sici=0027-8424%28199001%2987%3A1%3C118%3AAGOPSP%3E2.0.CO%3B2-V5Finding Sequence Motifs in Groups of Functionally Related ProteinsHamilton O. Smith; Thomas M. Annau; Srinivasan ChandrasegaranProceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 2.(Jan., 1990), pp. 826-830.Stable URL:http://links.jstor.org/sici?sici=0027-8424%28199001%2987%3A2%3C826%3AFSMIGO%3E2.0.CO%3B2-J5A Method to Identify Protein Sequences that Fold into a Known Three- DimensionalStructureJames U. Bowie; Roland Lüthy; David EisenbergScience, New Series, Vol. 253, No. 5016. (Jul. 12, 1991), pp. 164-170.Stable URL:http://links.jstor.org/sici?sici=0036-8075%2819910712%293%3A253%3A5016%3C164%3AAMTIPS%3E2.0.CO%3B2-Q5Improved Predictions of Secondary Structures for RNAJohn A. Jaeger; Douglas H. Turner; Michael ZukerProceedings of the National Academy of Sciences of the United States of America, Vol. 86, No. 20.(Oct. 15, 1989), pp. 7706-7710.Stable URL:http://links.jstor.org/sici?sici=0027-8424%2819891015%2986%3A20%3C7706%3AIPOSSF%3E2.0.CO%3B2-R7Methods for Assessing the Statistical Significance of Molecular Sequence Features by UsingGeneral Scoring SchemesSamuel Karlin; Stephen F. AltschulProceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 6.(Mar., 1990), pp. 2264-2268.Stable URL:http://links.jstor.org/sici?sici=0027-8424%28199003%2987%3A6%3C2264%3AMFATSS%3E2.0.CO%3B2-Thttp://www.jstor.orgLINKED CITATIONS- Page 2 of 8 -NOTE: The reference numbering from the original has been maintained in this citation list.10Protein Database Searches for Multiple AlignmentsStephen F. Altschul; David J. LipmanProceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 14.(Jul., 1990), pp. 5509-5513.Stable URL:http://links.jstor.org/sici?sici=0027-8424%28199007%2987%3A14%3C5509%3APDSFMA%3E2.0.CO%3B2-G15Strong Limit Theorems of Empirical Functionals for Large Exceedances of Partial Sums ofI.I.D. VariablesAmir Dembo; Samuel KarlinThe Annals of Probability, Vol. 19, No. 4. (Oct., 1991), pp. 1737-1755.Stable URL:http://links.jstor.org/sici?sici=0091-1798%28199110%2919%3A4%3C1737%3ASLTOEF%3E2.0.CO%3B2-S15Strong Limit Theorems of Empirical Functionals for Large Exceedances of Partial Sums ofI.I.D. VariablesAmir Dembo; Samuel KarlinThe Annals of Probability, Vol. 19, No. 4. (Oct., 1991), pp. 1737-1755.Stable URL:http://links.jstor.org/sici?sici=0091-1798%28199110%2919%3A4%3C1737%3ASLTOEF%3E2.0.CO%3B2-S16Limit Distributions of Maximal Segmental Score among Markov-Dependent Partial SumsSamuel Karlin; Amir DemboAdvances in Applied Probability, Vol. 24, No. 1. (Mar., 1992), pp. 113-140.Stable