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74 | JANUARY 2003 | VOLUME 4 www.nature.com/reviews/molcellbioPERSPECTIVESplate and sarcoplasmic components of mouse skeletalmuscle fibre as revealed by three dimensionalreconstructions from serial sections. J. Ultrastr. Res. 1,1–191 (1959).54. Revel, J. P. in Biochemistry of Muscle Contraction (ed.Gergely, J.) 232–246 (Little, Brown and Co., Boston, 1964).55. Franzini-Armstrong, C. & Porter, K. R. Sarcolemmalinvaginations constituting the T-system in fish musclefibres. J. Cell Biol. 22, 675–696 (1964).56. Huxley, H. E. Evidence for continuity between the centralelements of the triads and extracellular space in frogsartorius muscle. Nature 202, 1067–1071 (1964).57. Carafoli, E. Calcium signalling: a tale for all seasons. Proc.Natl Acad. Sci. USA 99, 1115–1122 (2002).58. Franzini-Armstrong, C. & Protasi, F. Ryanodine receptorsof striated muscles: a complex channel capable ofmultiple interactions. Physiol. Rev. 77, 699–729 (1997).59. Sacchetto, R., Turcato, F., Damiani, E. & Margreth, A.Interaction of triadin with histidine-rich Ca2+-bindingprotein at the triadic junction in skeletal muscle fibers. J. Muscle Res. Cell Motility 20, 403–415 (1999).AcknowledgementsWe apologize to those whose work could not be cited because ofspace restrictions.Online linksFURTHER INFORMATIONEncyclopedia of Life Sciences: CamilloGolgiAccess to this interactive links box is free online.43. Weber, H. H. The relaxation of the contracted actomyosinsystem. Ann. NY Acad. Sci. 81, 409 (1959).44. Muscatello, U., Andersson Cedergren, E., Azzone, G. F.& von der Decken, A. The sarcotubular system of frog skeletal muscle. A morphological and biochemical study. J. Biophys. Biochem. Cytol. 10,201–218 (1961).45. Muscatello, U., Andersson Cedergren, E. & Azzone, G. F.The relaxing effect of the sarcotubular system. Biochim.Biophys. Acta. 51, 426–428 (1961).46. Weber, A., Herz, R. & Reiss I. On the mechanism of therelaxing effect of fragmented sarcoplasmic reticulum. J. Gen. Physiol. 46, 679–702 (1963).47. Hill, A. V. The earliest manifestation of the mechanicalresponse of striated muscle. Proc. R. Soc. Lond. B 138,339–369 (1951).48. Huxley, A. F. & Taylor, R. E. Activation of a singlesarcomere. J. Physiol. 130, 49P–50P (1955).49. Fawcett, D. W. & Revel, J. P. The sarcoplasmic reticulumof fast-acting fish muscle. J. Biophys. Biochem. Cytol.10, 89–110 (1961).50. Porter, K. R. The sarcoplasmic reticulum: its recenthistory and present status. J. Biophys. Biochem. Cytol.10, 219–226 (1961).51. Bennet, H. S. & Porter, K. R. An electron microscopestudy of sectioned breast muscle of the domestic fowl.Am. J. Anat. 93, 61–106 (1953).52. Porter, K. R. & Palade, G. E. Studies on the endoplasmic reticulum. III. Its form and distribution instriated muscle cells. J. Biophys. Biochem Cytol. 3,269–300 (1957).53. Andersson Cedergren, E. Ultrastructure of motor end10. Mazzarello, P. The Hidden Structure. A ScientificBiography of Camillo Golgi. (transls and eds Buchtel, H.& Badiani, A.) (Oxford Univ. Press, 1999).11. Fusari, R. Sur l’imprégnation chromo-argentique desfibres musculaires striées des mammifères. Arch. Ital.Biol. 22, 89–91 (1895) (in French).12. Fusari, R. Encore sur l’imprégnation chromo-argentiquede la fibre musculaire striée des mammifères. Arch. Ital.Biol. 22, 91–95 (1895) (in French).13. Fusari, R. Sur la structure des fibres musculaires striées.Arch. Ital. Biol. 22, 95–98 (1895) (in French).14. Fusari, R. Studi sulla struttura delle fibre muscolari striate(Atti XI Congresso Internazionale di Medicina – Sezione diAnatomia, Rosemberg & Sellier, Torino, II: 49–50, 1894)(in Italian).15. Locatelli, P. Emilio Veratti. Rend. Ist. Lomb. Sci. Lett. 101,3–7 (1967).16. Berlucchi, G. Emilio Veratti and the ring of the czarina.Rend. Acc. Naz. Lincei. Sc. Mat. Fis. Nat. (in the press).17. Mazzarello, P. & Bentivoglio, M. The centenarian Golgiapparatus. Nature 392, 543–544 (1998).18. Veratti, E. Sulla fine struttura della fibra muscolare striata.Rend. R. Ist. Lomb. Sc. Lett. 35, 279–283 (1902) (in Italian).19. Bennett, H. S. in The Structure and Function of Muscle.(ed. Bourne, G. H.) 137–181 (Academic Press, New Yorkand London, 1960).20. Beams, H. W. Studies on the ‘Golgi apparatus’ of insectmuscle. Anat. Rec. 42, 323–334 (1929).21. Bentivoglio, M. & Mazzarello, P. The pathway to the celland its organelles: one hundred years of the Golgiapparatus. Endeavour 22, 101–105 (1998).22. Luna, E. Sulla fine struttura della fibra muscolarecardiaca. Arch. Zellforsch. 6, 383–386 (1911) (in Italian).23. Franzini–Armstrong, C. Veratti and beyond: structurecontributions to the study of muscle contractions. Rend.Acad. Lincei. (in the press).24. Szent-György, A. Lost in the twentieth century. Ann. Rev.Biochem. 32, 461–474 (1963).25. Marsh, B. B. A factor modifying muscle fibre synaeresis.Nature 167, 1065–1066 (1951).26. Goodall, M. C. & Szent-György, A. G. Relaxing factors inmuscle. Nature 172, 84–85 (1953).27. Portzehl, H. Die Bindung des Erschlaffungsfaktors vonMarsh an die Muskelgrana. Biochim. Biophys. Acta. 26,373–377 (1957) (in German).28. Kumagai, K., Ebashi, S. & Takeda, F. Essential relaxingfactor in muscle other than myochinase and creatinephosphokinase. Nature 176, 166 (1955).29. Briggs, F. N. & Fuchs, F. The biosynthesis of a muscle-relaxing substance. Biochim. Biophys. Acta.42, 519–527 (1960).30. Nagai, T. Makinose, M. & Hasselbach, W. Derphysiologische Erschlaffungsfaktor und die Muskelgrana.Bioch. Biophys. Acta 43, 223–238 (1960) (in German).31. Parker, J. C. & Gergely, J. Soluble relaxing factor frommuscle. J. Biol. Chem. 235, 3449–3453 (1960).32. Needham, D. M. in Structure and Function of Muscle II,(ed. Bourne, G. H.) 55–104 (Academic Press, New Yorkand London, 1960).33. Perry, S. V. Relation between chemical and contractilefunction and structure of the skeletal muscle cell. Physiol.Rev. 36, 1–76 (1956).34. Watanabe, S. & Sleator, W. EDTA relaxation of glycerol-treated muscle fibers and the effects of magnesium,calcium and manganese ions. Arch. Biophys. Biochem.68, 81–101 (1957).35. Weber, A. On the role of calcium in the activity ofadenosine 5-triphosphate hydrolysis of actomiosin. J. Biol. Chem. 234, 2764–2769 (1959).36. Weber, A. & Winicur, J. The role of calcium in thesuperprecipitation of actomiosin. J. Biol. Chem. 236,3198–3202 (1961).37. Ebashi, S. Calcium binding activity of vesicular relaxingfactor. J. Biochem. 50, 236–242


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