7.61 Fall 2004 for lectures 4 and 5 1 of 47.61 FALL 2004 RECEPTORS & SIGNAL TRANSDUCTION PART 2Background reading for Lectures 4 and 5 (October 4 and 6).Please read these before classThese two lectures and the associated discussion section (October 20) will cover various typesof receptor signaling systems and pathways.Alberts IV Chapter 15 - especially pages 871-900.ORLodish et al V Chapter 14Some of this material has already been covered in the lectures on receptors and G proteins.GeneralCurrent Opinion in Cell Biology – the second issue each year covers signalingHunter, T. (2000). Signaling – 2000 and beyond. Cell 100: 113-127An excellent overview of the past, present and future of signal transduction.Receptor Tyrosine KinasesSchlessinger, J. (2000) Cell signalling by receptor tyrosine kinases. Cell 103: 211-225.Reviews the evidence for receptor dimerization and activation and for recruitment ofsignaling molecules – excellent summary.Schlessinger, J. (2002). Ligand-induced, receptor-mediated dimerization and activationof EGF receptor. Cell 110: 669-672.Discusses the crystal structures of EGFR/EGF and EGFR/TGF- and cites earlier work on thestructures of other receptors receptors in complex with their ligands.Cho, H.S., Mason, K., Ramyar, K.X., Stanley, A.M., Gabelli, S.B., Denney, D.W., Jr., and Leahy,D.J. (2003). Structure of the extracellular region of HER2 alone and in complex with the HerceptinFab. Nature 421, 756-760.Van der Geer, P., Hunter, T. and Lindberg, R.A. (1994). Receptor Protein-tyrosine kinases andtheir signal transduction pathways. Annu. Rev. Cell Biol. 10:251-337.Thomas, S.M. and Brugge, J.S. (1997) Cellular Functions Regulated by src Family Kinases.Annu. Rev. Cell Dev. Biol. 13: 513-609.Heldin, C-H., Ostman, A. and Ronnstrand, L. (1998). Signal transduction via platelet-derived growthfactor receptors. BBA Reviews on Cancer 1378: F79-F113.Yarden, Y. 2001. The EGFR family and its ligands in human cancer. signalling mechanisms andtherapeutic opportunities. Eur J Cancer. 37 Suppl 4:S3-8.Kullander, K., and Klein, R. (2002). Mechanisms and functions of Eph and ephrin signalling. NatRev Mol Cell Biol 3, 475-486.Wells, A., and Marti, U. (2002). Signalling shortcuts: cell-surface receptors in the nucleus? Nat RevMol Cell Biol 3, 697-702.Carpenter, G. (2003). Nuclear localization and possible functions of receptor tyrosine kinases. CurrOpin Cell Biol 15, 143-148.7.61 Fall 2004 for lectures 4 and 5 2 of 4 Insulin Receptor and its SubstrateWaters, S.B. and Pessin, J.E. (1996). Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what atangled web we weave. Trends Cell Biol. 6:1-4.Myers, M.G., Sun, X.J. and White, M.F. (1994). The IRS-1 signaling system. Trends Biol. Sci.19:289-293.Keller, S.R. and Lienhard, G.E. (1994). Insulin signalling: the role of insulin receptor substrate-1.Trends Cell Biol. 4:115-119.Strålfors, P. (1997). Insulin second messengers. BioEssays 19:327-335.B and T Cell Receptor ComplexesQian, D. and Weiss, A. (1997). T cell antigen receptor signal transduction. Curr. Opin. Cell Biol.9:205-212.DeFranco, A. (1993). Structure and function of the B cell antigen receptor. Annu. Rev. CellBiol. 9:377-410.Crabtree, G.R. and Clipstone, N.A. (1994). Signal transmission between the plasma membraneand nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045-1083.Cytokine Receptors and SignallingOzaki, K., and W.J. Leonard. 2002. Cytokine and cytokine receptor pleiotropy and redundancy. JBiol Chem. 277:29355-8.O'Shea, J.J., M. Gadina, and R.D. Schreiber. 2002. Cytokine signaling in 2002: new surprises inthe Jak/Stat pathway. Cell. 109 Suppl:S121-31.Watowich et al. (1996). Cytokine receptor signal transduction and the control of hematopoeiticcell development. Annu. Rev. Cell Dev. Biol. 12:91-128.Schindler, C. and Darnell, J.E. (1995). Transcriptional responses to polypeptide ligands: theJAK-STAT pathway. Anuu. Rev. Biochem. 64:621-651.Ihle, J.N. (1995). Cytokine receptor signalling. Nature 377:591-594.Darnell, J.E., Ker, I.M. and Stark, G.R. (1994). JAK-STAT pathways and transcriptionalactivation in response to IFNs and other signalling proteins. Science 264:1415-1421.Taniguchi, T. (1995). Cytokine signalling through nonreceptor protein tyrosine kinases. Science268:251-255.Darnell , J.E. (1997). STATs and gene regulation. Science 277:1630-1635.Brivanlou, A.H., and Darnell, J.E., Jr. (2002). Signal transduction and the control of geneexpression. Science 295, 813-818.7.61 Fall 2004 for lectures 4 and 5 3 of 4TGFβ-Receptors and SignallingShi and Massague (2003) Mechanisms of TGF-β signaling from cell mebrane to nucleusCell 113:685-700.Massagué, J., Bkain, S.W. and Lo, R.S. (2000) TGF-β signaling in growth control, cancerand heritable disorders. Cell 103: 295-309.Massagué, J. (2000). How cells read TGFβ signals. Nat. Rev. Mol. Cell Biol. 1: 169-178.Alevizopoulos, A. and Mermod, N. (1997). Transforming growth factor-β: the breaking open of ablack box. BioEssays 19:581-591.Tyrosine PhosphatasesHermiston et al. (2002) Reciprocal regulation of lymphocyte activation by tyrosinekinases and phosphatases. J. Clin. Invest. 109: 9-14.Billadeau and Liebson (2002) ITAMs versus ITIMs: striking a balance during cellregulation. J. Clin. Invest. 109: 161-167..Charbonneau, H. and Tonks, N.K. (1992). 1002 Protein phosphatases. Annu. Rev. Cell Biol.8:463-494.Frearson, J.A. and Alexander, D.R. (1997). The role of phosphotyrosine phosphatases inhematopoietic cell signal transduction. BioEssays 19:417-427.Biwes et al (1996) Structural basis for inhibition of receptor protein-tyrosine phosphatase-a bydimerization. Nature 382: 555- 559.Jiang et al. (1999) Dimerization inhibits the activity of receptor-like protein-tyrosinephosphatase-a. Nature 401: 606-610.Receptor DownregulationThien CBF and Langdon WY (2001) Cbl: many adaptations to regulate protein tyrosine kinases.Nature Rev Mol Cell Biol. 2: 294-305.PI3 KinasesCzech, M.P. (2000) PIP2 and PIP3: complex roles at the cell surface. Cell 100: 603-606.Rameh, L.E. and Cantley, L.C. (1999). The role of phosphoinositide-3-kinase lipid products incell function. J.Biol.Chem. 274: 8347-8350.Carpenter, C.L. and Cantley, L.C. (1996). Phosphoinositide kinases. Curr. Opin. Cell Biol.8:153-158.Toker, A. and Cantley, L.C. (1997). Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature