Biochemistry and Molecular Biology 461 Fall Semester 2011 Lectures 9 10 10 00 a m MWF 1281 Anthony Hall Course Coordinator Jon Stoltzfus PhD Instructor of Biochemistry and Molecular Biology 305 Biochemistry Building Tel 517 432 8775 Email stoltzfu msu edu must include BMB461 in the subject line Office Hours Tuesday 10 30 11 30 a m Wednesday 2 00 3 00 p m Thursday 1 00 2 00 p m or by appointment Instructors Christoph Benning PhD Professor of Biochemistry Molecular Biology 215A Biochemistry Building Tel 517 355 1609 Email benning msu edu must include BMB461 in the subject line Office hours Flexible by Email appointment Eric Hegg PhD Associate Professor of Biochemistry Molecular Biology 510A Biochemistry Building Tel 517 353 7120 Email erichegg msu edu must include BMB461 in the subject line Office hours Monday 10 30 11 30 a m Thursday 4 30 5 30 p m Graduate Student Assistant The graduate student assistant for BMB 461 is listed below with his contact information The graduate student will be available to answer student questions The primary venues for these graduate student interactions are office hours and weekly review sessions recitations which will consist of a short presentation followed by an open question period Due to the large size of the lecture sessions students are encouraged to take advantage of these opportunities for small group instruction Graduate student Adam Cornish Email cornish5 msu edu Graduate student office hours Graduate student review sessions Tuesdays 5 45 7 15 p m in BCH502 Wednesdays 6 10 7 40 p m in BCH101 During exam weeks instructors will lead the review sessions from 6 10 p m 7 40 p m in BCH 101 These instructor led review sessions will occur on the following days Wednesday September 21 Wednesday October 19 Wednesday November 9 Prior to the final exam an instructor led recitation will be held on Friday December 9 from 4 00 5 30 p m in BCH 101 1 Course Structure This three credit course will be given as three hour long lectures per week MWF at 9 10 a m Homework assignments will be posted on ANGEL www angel msu edu These assignments will be neither collected nor graded Nevertheless the problem sets are an essential part of the course and completion will prepare students for the exams Working in groups on the problem sets is encouraged There are also questions in the textbook at the end of each chapter Students should incorporate these questions into their studies The answers to these questions are provided in the back of the book Important course materials including homework and lecture notes will be posted on the ANGEL website Multiple choice questions from previous year s exams arranged by topic will be available in LON CAPA www loncapa msu edu Students are expected to check these sites regularly for newly posted material Course Objectives BMB 461 is the first semester of the undergraduate series BMB 461 462 which provides students with an introduction to biochemistry at the advanced undergraduate level BMB 461 reintroduces basic biochemistry concepts including protein structure and function and focuses on carbohydrate and energy metabolism The following topics will be discussed during this term Buffers pH Protein Structure Protein Purification Protein Ligand Binding Enzyme Catalysis and Mechanism Enzyme Kinetics Carbohydrates Glucose Metabolism Pentose Phosphate Pathway Glycogen metabolism and regulation Citric Acid Cycle Glyoxylate Cycle Electron Transport Oxidative Phosphorylation Photosynthesis Textbook Nelson D L and Cox M M Lehninger Principles of Biochemistry 5th ed 2008 W H Freeman New York 1158 pages Note on Introductory Material BMB461 is an integrative course that draws on material covered in undergraduate biology introductory chemistry and organic chemistry Chapter 1 of your textbook Lehninger Principles of Biochemistry D L Nelson and M M Cox 5th ed provides a useful review of several topics from these prerequisite courses We will not cover this material directly in lecture but students who encounter difficulty with terms concepts or calculations encountered in class are encouraged to consult this section of the book for a useful review Lecture Notes We will not assemble a printed course pack in advance Instead we will heavily rely on ANGEL for postings of materials Lecture notes will be posted in advance of the lectures You can print them out in your preferred format and bring them to class Many of the slides will be identical to figures in the book and you might consider bringing your book instead You should consult the figure legends in the book and the relevant text for studying purposes 2 Course Recordings We will be recording the audio and projected material from each lecture using the Camtasia system and posting the recordings on the course ANGEL site Keep in mind that it is at the instructor s discretion to turn on the recording only after announcements regarding exams etc have been made It is important to emphasize that BMB461 is not an online course We strictly recommend against relying on the recordings as a substitute for lecture attendance Technical issues with Camtasia may occasionally cause the recording and or posting of lectures to fail and such events are not considered an excuse for missing the covered material More importantly research shows that the best way to use Camtasia is to attend the live lecture take good notes and then use the recordings as a resource to go back over material you may have missed or not completely understood It helps to mark down the time during lecture at which you have trouble understanding so that you can later skip quickly to the section in question Clickers This course will use i clickers to facilitate active learning Clickers may be registered at the beginning of lecture any time during the first two weeks of the semester If you do not register your clicker during this time you may not receive credit for previous clicker questions During each lecture you will have one or more opportunities to answer questions using the clicker You will receive 9 10th of a point for sending in any answer and an additional 1 10th of a point for sending in the correct answer Some questions are designed to generate discussion and may not have a correct answer In this case you will receive one point for any answer To receive full credit for i clickers you only need to earn 90 of the possible clicker points points earned possible points 9 points received Clicker points for the entire semester are worth 4 of