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UNC-Chapel Hill ENVR 132 - ENVR 132 Final exam guide

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ENVR 132/TOXC 142/BIOC 142 Spring 2005 1Final Exam Guidelines Due on or before 10 AM, Tuesday, May 10, 2005. Send via campus mail to Ivan Rusyn CB#7431, or e-mail as an attachment to [email protected] Original research papers for the final exam (available in PDF format on the course website): Free Radic Biol Med. 2005 38:58-69. Cytotoxicity studies of chromium(III) complexes on human dermal fibroblasts. Shrivastava HY, Ravikumar T, Shanmugasundaram N, Babu M, Unni Nair B. Environ Health Perspect. 2005 113:83-87. Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor. Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E, Robertson LW. Carcinogenesis. 2005 26:503-509. Gene expression profiling of chemically induced rat mammary gland cancer. Shan L, Yu M, Snyderwine EG. Hepatology. 2005 41:187-195. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Su GL, Gong KQ, Fan MH, Kelley WM, Hsieh J, Sun JM, Hemmila MR, Arbabi S, Remick DG, Wang SC. For the final exam you are asked to select ONE published manuscript from 4 listed above, carefully read the paper, and prepare a 3-4 page (double-spaced) review/critique of this study using the guidelines provided below. The use of textbooks, lecture notes and other appropriate material is encouraged. Feel free to engage in discussion with your peers/advisors. However, this is not a collective work! Each student must submit an independent answer. The maximum score for this exam is 105 points, or 35% of the total course grade.ENVR 132/TOXC 142/BIOC 142 Spring 2005 2Guidelines for preparation of the final exam: I suggest the following strategy: read the paper once, or several times to understand the general concept(s), study design, results and conclusions. Go to PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi and search by keywords going back 3-5 years. Review the abstracts (or if necessary the full-text versions) of papers that are related to the topic of your selected publication. Try to understand what others have done in this area, what prior knowledge led the authors to this particular study, and how does this study move the field forward. It might be also helpful to review recent (last 3-5 years) papers by this group of authors to understand how they came to a particular research question that was addressed in this manuscript. Please use the sample questions that one might ask him(her)self while reading a(ny) research paper that are provided below. The list below is not inclusive and feel free to add to it as you see other issues that get your attention. Do not simply try to answer each and every question. The format of your answers should read as a cohesive essay. It is expected that your essay will contain at least three paragraphs (sections) that address each of the following: 1. Summary of the paper (5-7 sentences that capture the highlights of this study). 2. General comments/critique: What is the knowledge base for this study? What was the hypothesis of this study? Does this paper address a novel question and/or uses novel experimental approach? What was the experimental approach? Is the paper clear and well organized? Is the study focused? Is the experimental model appropriate to address the hypothesis? Is the experimental design sound? Does this paper contain new findings/ideas? Are conclusions supported by the data? How this paper advances our existing knowledge (i.e., why is it important)? How does this study compare with other papers that you have read? Is this manuscript appropriate for this journal? 3. Comments/critique to specific sections of the manuscript: Abstract: Is it concise and clear? Is information provided sufficient to provide general understanding of the work? Introduction: Is it concise and clear? Does it contain enough background information for a reader who is not an expert in this line of research? Are references useful and contain additional more extensive information?ENVR 132/TOXC 142/BIOC 142 Spring 2005 3After reading the Introduction do you feel ready to understand what are the critical gaps in our knowledge that this study will address? Methods: Contains sufficient experimental detail? Would you be able to repeat the experiments in your own lab by following described experimental procedures? Results: Clarity of presentation? Are Figures easy to understand? Figure legends provide necessary details to understand what is shown and what the experiment was? Are there inconsistencies in data presentation? Is data repetitive? Is some of the “data not shown” essential for understanding the study and should have been shown? Is there an assay/endpoint that you wish have been looked at in this study? Discussion: Does it repeat the results? Are conclusions supported by the actual data? Does it address the importance of this study for the advancement of science in this area? Did authors think of yet unanswered questions/ future directions? References: Too many/too few? Are references appropriate/helpful? Are there any additional key papers that you feel should have been included? Do the authors cite their own work too often (is there an obvious bias


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