Syllabus Dr. Peter Wipf [1301 CHVRN], 412-624-8606 CCHHEEMMIISSTTRRYY 11114400 12-12:50 PM M; 8:00-11:50 AM T H; THAW 300 ADVANCED INORGANIC CHEMISTRY LABORATORY This course is an introduction to modern concepts and experimental techniques in inorganic and organometallic chemistry. The lectures emphasize the specific experimental techniques required for the laboratory, as well as the inorganic and organometallic principles that are the foundation of the experiment(s) being performed. Laboratory lectures will also be, as much as possible, integrated and related to the Inorganic Chemistry course, Chem 1130. Experiments emphasize protocols that showcase important inorganic and organometallic reaction mechanisms and modern laboratory techniques used routinely in synthetic research and development laboratories. There are 2 lab sections. Due to very limited space and the need to work in a well-vented hood, it is not possible to switch between these sections. Space, and, accordingly, safety precautions also do not permit making up missed lab sessions. Lab coats and eye protection need to be worn at all times in the laboratory. The course will start on January 10th. First week assignment: Read Chapters 1-6 of Szafran et al.2 CLASS SCHEDULE (preliminary and subject to changes) January 10 Safe Laboratory Practices; Ferrocene January 11, 13 Preparation of Ferrocene January 17 No Class (MLK Birthday) January 18, 20 Acetylation of Ferrocene January 24 Spectroscopy January 25, 27 Characterization of Ferrocene & Derivatives January 31* Molecular Modeling February 1, 3 Synthesis & Characterization of Wilkinson’s Catalyst February 8, 10 Introduction to Organometallic Chemistry February 8, 10 Reaction of Wilkinson’s Catalyst with Aldehydes February 14 Catalysis February 15,17 Catalytic Hydrogenation with Wilkinson’s Catalyst February 21* Techniques for Handling Air-Sensitive Compounds February 22, 24 Preparation of Ruthenium Olefin Metathesis Catalyst February 28 Transition Metal-Catalyzed Olefin Metathesis March 1, 3 Ring-Closing Metathesis (RCM) March 7-11 No Class (Spring Break) March 14 Ring Opening Metathesis Polymerization (ROMP) March 15, 17 Polymerization of Cyclooctadiene March 21* Bioinorganic Chemistry March 22, 24 Cobaloximes: Models of Vitamin B12 March 28 Platinum Complexes March 29, 31 Preparation of cis-Diaminediiodoplatinum(II) April 4* Organometallic Reaction Mechanisms April 5, 7 Preparation of Cisplatin April 11 Mechanism of Action of Cisplatin April 12, 14 Biological Activity of Cisplatin; Potato disk assay April 18 Lab Final April 19, 21 Potato disk analysis & Lab Cleanup April 22* submit all lab reports and your lab notebook * Lab report due date; please submit reports to your laboratory instructor before 6 PM. Personal course materials can be picked up from CHVRN 1303 (Ms. Michelle Woodring) from 9 AM to 5 PM starting May 2nd to October 3rd, 2005.3 Texts: 1. The required text for this course is Microscale Inorganic Chemistry; A Comprehensive Laboratory Experience by Zvi Szafran, Ronald M. Pike, and Mono M. Singh; Wiley 1991. This text provides a detailed coverage of safety, equipment, laboratory reports, literature searches, lab techniques, and spectroscopy in Chapters 1-6 that is required reading before starting experiments and will be tested in the lab final. In addition, several experiments are taken from this text. 2. Keeping a continuously updated laboratory notebook is required at all times. 3. A recommended text, for gaining a broader overview, is D. Shriver, P. Atkins Inorganic Chemistry, 3rd ed; Freeman: New York, 1999. 4. Useful, but not required: G. S. Girolami, T. B. Rauchfuss, R. J. Angelici Synthesis and Technique in Inorganic Chemistry, 3rd ed; University Science Books: Mill Valley, 1999. 5. Additional reading materials will be assigned and posted on our website. Office Hr's: Tuesdays at 5:30-6:30 PM in Chevron 1301, or by appointment. Lab Instructors: Juan Arredondo and Jim Mignone. Web page: For updated course information, check our course web site at http://ccc.chem.pitt.edu/wipf/Courses/1140_05.html. Grading Policy: Final grades will be assigned based on the following guidelines: • Experimental Results and Data; Lab Notebook 200 points • Formal Laboratory Reports 500 points • Technique, Preparation and Participation 100 points • Lab Final 200 points Total 1000 points Lab Final: this 1 h exam will cover all the background material from assignments and lectures as well as the actual experiments. You will be able to use your laboratory notebook, but no other reference source. Loose pages are not permitted. Academic Integrity: All work should be your own. Collaboration beyond the stage of a “helpful discussion” is a violation of the Academic Integrity Code of the University of Pittsburgh (http://www.pitt.edu/~provost/ai1.html). Scientific research requires honesty and integrity, and cheating in any form (i.e. copying data, plagiarism, using unauthorized information, etc) is a violation of Academic Integrity and will result in disciplinary actions, including a failing grade for the entire course and notification of the Dean of A&S.4 Attendance: You cannot perform an experiment unless you are in the lab. Due to the large number of students taking this course and the space and safety restrictions, it will be impossible to make up for a missed lab. Also, several experiments use material prepared in an earlier lab. Excused absences consistent with the University Absence Policy will be dealt with as required. If you are aware of any preexisting reason that will require you to miss a laboratory, you must inform me in writing no later than 15 January 2004. Attendance at the Monday lectures is a prerequisite for being able to perform an experiment. Collaboration with Pitt Johnstown: We will share information on some experiments with Prof. Lisa Bell-Loncella’s Chem 1133 class at UPitt Johnstown. Professor Bell-Loncella has set up a BlackBoard site for her course on courseweb.pitt.edu. Safety: Safety in the laboratory is of paramount importance. The most important