BIOC/CHEM/MMG 205, Biochemistry IUniversity of VermontFall Semester, 2003Instructors Office Phone E-mailMargaret Daugherty Given B409 656-0344 Margaret.Daugherty @uvm.eduMartin Case Cook A321 656-8264 [email protected] Time:Mon/Wed/Fri 9:05 - 9:55, Votey room 105Required Text:Principles of Biochemistry with a Human Focus, 1997, Garrett & GrishamOrganization:Problem Sets, 6 x 4% (3 for Daugherty, 3 for Case) 24%Exams, 4 x 15% 60%Comprehensive Final Exam (multiple choice) 16%100%Problems sets will be assigned throughout the course. Exams will last 115 minutes - from8 am to 9:55 am in the classroom. If you have any scheduling conflicts with the earlytime slot, please notify the appropriate professor prior to the exam to reschedule. Examsare closed-book, closed-note exams; no class materials may be used and no outside helpmay be used. Due to potential scheduling conflicts, you are not allowed to discuss theexams with anyone else until the answer key is posted. The final exam is cumulative andwill occur during the final exam time slot.Website:All lecture notes, homeworks and answer keys, and other interesting "items" will beposted as pdf files on a website at http://biochem.uvm.edu/undergradcourses.phplogin: biochemistrypassword: greatfunGood stuff to know for Part I: Protein Structure & FunctionDr. Daugherty Phone: X60344Office: Given B409Email: [email protected] hours by appointment - don't hesitate to contact me to make an appointment!I encourage students to contact me by email with the smaller "clarification" types ofquestions. I usually respond to emails by the end of the day.Exam I: Monday 9/29/03 from 8:00 - 9:55 am (comprised of Lectures 1 - 11)Exam II: Monday 10/20/03 from 8:00 - 9:55 am (comprised of Lectures 12 - 18)Exams will be held in the classroom!Absence from an exam requires prior approval from Dr. Daugherty.Homework is ABSOLUTELY due by the end of class on the due date. Late homework willbe severely penalized !. Homework will be returned at the end of the following classperiod, along with an answer key.*Review questions (answers in back of book) are for your benefit only - they reflect thetype of questions & information that may be asked on the exam!Review sessions to be held by Dr. Daugherty are Monday from 5:00 - 7 pm in GivenBuilding, Room C443. There will be no review session on Monday, Sept 8.Selected copies of old exams/homeworks for my material are "on reserve" in DanaLibrary.Teaching assistant: Brian EckenrothOffice hours: TBAOffice location: TBAEmail: [email protected] 205: BIOCHEMISTRY I SYLLABUSDr. Margaret (Peggy) [email protected] Building Room B409Office: 656-0344Office hours by appointmentLecture Date Topic Reading &Review Questions*GradedHomework1W9/3Introduction & Review ofFundamentalsCH 1: p 2 - 26Review questions:1, 6-102F9/5Review: Water, pH and pKa CH 2: p 31 - 49Review questions:1a,d;2a,e,3,6Homework 1out3M9/8Review of Thermodynamics CH 3: p 51 - 67Review questions:1,2,5,10,114W9/10Amino Acids: The Primary Level ofProtein Structure; Amino Acids asPolyprotic AcidsCH 4: p 68 - 81Review questions:2,3,4,65F9/12Protein Architecture I: Peptidesand the Peptide BondCH 4: p 85 - 87CH5: p 118-121Review questions:CH5: #46M9/15Protein Architecture II:Secondary StructureCH 5: p 113 - 126Review questions: 1,8Homework 1due;Homework2 out7W9/17Protein Architecture III:Tertiary, Quaternary StructureCH 5: p 127 - 149Review questions 2,78F9/19Protein Architecture IV: Tertiary,Quaternary Structure9M9/22Protein Architecture V:Evolution, Function, Classificationof ProteinsCH 4: p 101 - 111Review questions10 W9/24Protein & Peptide Chemistry CH 4: p 82 - 84 and88 - 100Review questions 15Homework 2due:Homework3 out11 F9/26Protein Folding and Stability CH 5: p 140 - 149Review questions: 312 M9/29EXAM 1 ☺☺☺☺: 8 - 9:55 AMLectures 1 - 1113 W10/1Enzymes & Kinetics I:Introduction to Enzymes andKineticsCH 10: 320 - 326Review questions14 F10/3Enzymes & Kinetics II: Michaelis-Menton KineticsCH 10: 326 - 332Review questions1,2,315 M10/6Enzymes & Kinetics III: MichaelisMenton Kinetis & InhibitionCH 10: 332 - 341Review questions 416 W10/8Enzymes & Kinetics IV: MichaelisMenton Kinetis & InhibitionCH 10: 332 - 341Review questions 417 F10/10Fall Recess - No class!18 M10/13Enzymes & Kinetics V: Regulation& AllosteryCH 10: 343-359Review questions 919 W10/15Enzymes & Kinetics VI:MechanismsCH 11: 363 - 381Review questions 3.5Homework 3due; Homework4 out with key.20 F10/17Proteins of the Blood I:Hemoglobin & Myoglobin -Comparison of FunctionCH 12: 398 - 411Review questions5,621 M10/20EXAM 2 ☺☺☺☺: 8:00 - 9:55 AMLectures 13 - 20Chem 205Tentative Syllabus, Fall 2003, Metabolism.Martin Case instructorAll lectures 9:05 to 9:55 amDate Lecture Topic10-22 1 Introduction to metabolism; bioenergetics10-24 2 Vitamins and cofactors10-27 3 Glycolysis I10-29 4 Glycolysis II10-31 5 Glycolysis III11-3 6 Glycolysis IVProblem Set 411-5 7 TCA cycle I11-7 8 TCA cycle II11-10 9 TCA cycle IIIProblem Set 4 dueExam 311-12 10 Gluconeogenesis I11-14 11 Gluconeogenesis IIProblem Set 511-17 12 Oxidative phosphorylation I11-19 13 Oxidative phosphorylation II11-21 14 Photosynthesis I11-24 15 Photosynthesis IIProblem Set 5 dueExam 412-1 16 Lipid metabolism I12-3 17 Lipid metabolism IIProblem Set 612-5 18 Lipid metabolism III12-8 19 Lipid metabolism IV12-10 20 Review of metabolismProblem Set 6