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DARTMOUTH ENGS 167 - DEPTH METHODS & ROC ANALYSIS OF IMAGES

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11/20/200611ENGG 167 MEDICAL IMAGINGLecture 14: Wednesday, Oct 25Depth Methods & ROC Analysis of Images References: Chapter 10, The Essential Physics of Medical Imaging, BushbergIntermediate Physics for Medicine and Biology, Hobbie, 3rded.Principles of Computerized Tomographic Imaging, Kak and Slaney.(http://rvl4.ecn.purdue.edu/~malcolm/pct/pct-toc.html)Rizzoni, Principles and Applications of Electrical Engineering, 4thed., McGraw Hill21) X-ray imaging with digital subtraction Ref: Bushberg11/20/2006232) Dual energy imagingRef: Bushberg4Dual energy subtraction imagingRef: Bushberg11/20/2006353) – Tomosynthesis – approaching computed tomographyRef: Bushberg63) Breast Tomosynthesis – in investigational studiesRef: http://deckard.duhs.duke.edu/~jyl/bme.html11/20/200647Breast Tomosynthesis – in investigational studiesRef: Steve Poplack, M.D.84) Receiver Operator Characteristic (ROC) AnalysisRef: BushbergHow do you assess if the imaging method is leading to improved detection and characterization of the disease ?Use a well determined set of images and have blinded readers assess the images and determine the sensitivity and specificity of the images at detection of disease.11/20/2006594) Receiver Operator Characteristic (ROC) AnalysisRef: Bushberg104) Alternative metrics of accuracy in diagnosisRef: Bushberg11/20/20066114) Receiver Operator Characteristic (ROC) AnalysisRef: Bushberg1-124) ROC analysisRef: Bushberg11/20/20067135) Example of ROC analysis in current literature-145) Example of ROC analysis in current literature-5 radiologists participating44 malignant & 18 benign, Numeric score for each morphologic criteria: 1) lesion contour2) homogeneity of contrast3) lesion shape4) presence of ring enhancement11/20/20068155) Example of ROC analysis in current literature-χ-coefficient is inter-oberver agreement – generally below0.5 is too low.166) Lab this week Thursday noon - 1:00pmFriday noon - 1:00pmCT Scanner in Radiation OncologyEnter through the Borwell Building (level 5), and take the elevator down to level 2 (similar to the lab 1). We will meet as a group in front of the irradiator (where we did lab 1). Once we are sure there are no patients in the CT room, we will enter the cancer center as a group to go into the CT room.If you arrive after 12:10, here are the directions to find the CT room. Turn right out of the elevator on level 2. Then take the first double doors on the right into the Norris Cotton Cancer Center, Rubin Building. The CT room is directly down this hall on the right, look for the sign.Show up to one


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DARTMOUTH ENGS 167 - DEPTH METHODS & ROC ANALYSIS OF IMAGES

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