Daltons Law:Patom = PN2 + PO2 + Pco2……carbonic anhydrase CO2 + H2O H2CO3 H+ +HCO3oxyhemoglobinFactors that influence hemoglobin affinity for O2:In PO2= increase affdecrease H+= decrease PCO2 == inc affinitydecrease temp = increase affindecrease DPG(lots of oxygen) = inc affinity (less oxygen = more affinity)In tissue: ( all of these examkples decrease affinity; need oxygen to come off in tissue so need that decrease in affinity)decrease PO2increase PCO2, H+, decrease pHincrease tempincrease DPGOxygen-hemoglobin dissociation curve:shift to the right= decrease affinity; is this good or bad? depends on where im at if i had this shift to the right in the lungs thats bad; in the tissue its good.inc dpginc tempdecrease pHshift for pH= borr shiftshift for temperatureshift for DPGCO2 transport:Dissolved in plasma= 10%(small but significant)bound to hemoglobin= 30% (somewhere between the other 2))bicarbinate = 60% (most)chloride shift11/5/13 11/05/2013Daltons Law:- Patom = PN2 + PO2 + Pco2……-- carbonic anhydrase -CO2 + H2O H2CO3 H+ +HCO3-oxyhemoglobinFactors that influence hemoglobin affinity for O2:-In PO2= increase af-decrease H+= decrease PCO2 == inc affinity-decrease temp = increase affin-decrease DPG(lots of oxygen) = inc affinity (less oxygen = more affinity)In tissue: ( all of these examkples decrease affinity; need oxygen to come of in tissue so need that decrease in affinity)-decrease PO2-increase PCO2, H+, decrease pH-increase temp-increase DPGOxygen-hemoglobin dissociation curve:---shift to the right= decrease affinity; is this good or bad? depends on where im at if i had this shift to the right in the lungs thats bad; in the tissue its good. oinc dpgoinc tempodecrease pH-shift for pH= borr shift-shift for temperature-shift for DPGCO2 transport:-Dissolved in plasma= 10%(small but significant) -bound to hemoglobin= 30% (somewhere between the other 2))-bicarbinate = 60% (most)chloride