Hey Tom, Can you tell your honors bio kids about this? Might be useful for some of them.... *******Do you need help with your resume or CV? Worried about how it will look to prospective supervisors? We can help!!!****** CV/RESUME WORKSHOP FOR UNDERGRADS****** The Graduate Women in Science organization will be running a free workshop on building a strong CV or resume. Although the workshop is geared toward undergrads from any science major, ALL ARE WELCOME! We'll discuss strategies and tips for how to compose a professional CV/resume and how to tailor a resume for different purposes, including graduate school applications and research positions. There will be sample CVs and resumes to use as models, and students will also have a chance to get one-on-one help with their CVs and resumes from competent graduate students spanning multiple disciplines. ***When: Tuesday, November 2, 6pm ***Where: Natural Sciences Room 204 Feel free to bring your current CV/resume with you to the workshop! Once again, students from ALL FIELDS are welcome. Hope to see you there. Questions? Email Leslie at [email protected] Leslie CurrenPh.D. Candidate: Ecology, Evolutionary Biology, and Behavior Michigan State University https://www.msu.edu/user/currenleOverview of Lecture: Nervous systems. Read: Text ch 48 & 49. Bullet Points: • nervous systems • neurons • info processing - reflexes • resting & action potentials • synapses & mechanisms • transmitters • autonomic NS • CNS • depression • addiction • synaptic plasticity & learning • sex differencesCNS PNS PNSMyelinated CNS = ‘white matter’ unmyelinated CNS = ‘gray matter’ oligodendrocytes & glia: CNS neuroglia → myelin Schwann cells: PNS neuroglia → myelin synapseGlia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans DA Colón-Ramos et al. 2007. Science 318: 103 – 106. Glial cells are important in neural development of functional connections A cultured sensory neuron extending a growth cone with long thin filopodia, photo by Ken BalazovichThe linked image cannot be displayed. The file may have been moved, renamed, or deleted. Verify that the link points to the correct file and location.+ - α So, how can you move? http://en.wikipedia.org/wiki/Reflex Adult human reflexes Baby reflexes not seen in adultsWater-soluable Ions cannot dissolve in the phospholipid plasma membrane; they must either be pumped by membrane proteins or diffuse through ion channels, which are aqueous pores made of specific transmembrane protein molecules. These molecular channels are selective for specific ions.threshold ~ - 55mVhttp://www.driesen.com/ssri_actions.htm Extasy (MDMA) is a serotonin reuptake inhibitor; cocaine is a dopamine reuptake inhibitor Receptors move in and out of plasma membrane.see Text Fig 49.8 Each autonomic pathway consists of a preganglionic neuron w/ its cell body in the CNS and a postganglionic neuron w/ its cell body in a ganglion outside the CNS. celiac (solar) plexus (finish sex) (begin sex) Excite: dilate pupils Fight or Flight Relax: constrict pupils Rest & Digest Ach Ach Nepi Achhttp://www.csuchico.edu/psy/BioPsych/neurotransmission.html • Each time you move a muscle it is because acetylcholine (Ach) has been released from a neuron to activate muscle Alzheimer's Disease is associated with a 90% loss in the brain's production of Ach in the basal forebrain and hippocampus. Nicotine mimics Ach at neuromuscular junction, autonomic & CNS. • GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the brain. • GLU (glutamate) is the main excitatory neurotransmitter in the brain. Its actions are mediated at two types of receptor (NMDA and AMPA) involved in memory formation • Endorphins/Enkephalins are endogenous opiates found in a variety of places in brain. They are also released as hormones by the pituitary. They are involved in pain reduction and pleasure (they enhance the effects of dopamine). • Human mood disorders (depressions) are treated with drugs that block the reuptake of serotonin (5-HT) into the presynaptic axon terminal, for example fluoxetine (Prozac). A good source of info: http://en.wikipedia.org/wiki/Neurotransmitter • NO {Viagara} & Adenosine {caffeine} ! • Cocaine, opiates, nicotine and alcohol produce rewarding effects by promoting the release or inhibiting the presynaptic re-uptake of dopamine. {addiction is associated with reduced density of dopamine receptors:} Parkinson's Disease (PD) is accompanied by a selective destruction of dopamine neurons in the substantia nigra of the midbrain. PD is treated with L-dopa, a precursor of dopamine in the brain. Schizophrenia is treated with drugs which block the binding of dopamine to its postsynaptic receptor sites. Nature 419, 872-874 (2002) {MAO inhibitors ↓ breakdown} {SSRIs ↓ serotonin reuptake} see Table 48.1Health & Science Study Sheds Light on How Depression Drugs Work by Jon Hamilton Antidepressants and electroconvulsive therapy (ECT) all caused an increase in the amount of p11 in the brains of mice. So, it’s pretty convincing that p11 is associated with the main therapeutic action of antidepressant drugs. http://www.nih.gov/news/pr/jan2006/nimh-06.htmhttp://www.nature.com/news/2010/101020/full/news.2010.551.html#comments Research published today in Science Translational Medicine uses a virus to deliver an extra dose of the gene p11 to the adult mouse brain. The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighbouring cells.… there was a significant reduction in [C-11]SCH 23390 binding potential in smokers compared to nonsmokers in the ventral striatum. {# D1 dopamine receptors ↓ in smokers & therefore ↓ of the D1 label bound} Such a hypodopaminergic state may play an important role in sustaining nicotine-seeking behavior. {need hyperstimulation of few remaining dopamine receptors in ‘pleasure centers’?} Eleven neuronal nAChR subunits {genotypes} have been identified in humans ... with distinct functional properties and pharmacological characteristics Tapper et al. (Science 306, 1029-1032 (2004)