Quantitative Physiology: Cells and Tissues Lecture 34: December 11, 2006(Volume 2: 6.6.2-6.6.3 6.7)MembraneIntracellularExtracellular+++−tVm(t)VimVimVfmm(Vm, t)τm(Vim)GNa(Vm, t)τG(Vim)JNa(Vm, t)τJ(Vim)Figure 6.58−100 −75 −50 −25 0 25 50 750.20.40.60.8 (ms) (mV)VmτJτmFigure 6.59MembraneIntracellularExtracellular+++αmβmC3C2C1Oαmβm3αm2αm2βm3βmFigure 6.54mmm hmmh m h hmmmm mmmmmmmmmmmm mmh h h hαmβm3αm2αm2βm3βmαmβm3αm2αm2βm3βmαhβhαhβhαhβhαhβhFigure 6.55αmβm3αm2αm2βm3βmαmβm3αm2αm2βm3βmαhβhαhβhαhβhαhβhS1S2S3S4S5S6S7S8γ1= 0γ2= 0γ3= 0γ46= 0γ5= 0 γ6= 0γ7= 0γ8= 0Figure 6.56S1S2S3S4S5α12α23α34α45α51α21α32α43α54α15γ1, Q1γ2, Q2γ3, Q3γ4, Q4γ5, Q5Figure 6.600State occupancy, Single-channelconductance, Single-channelcurrent, 0TimeSingle-channelgating charge, Single-channelgating current, ˜ig˜i˜s˜g˜qgS1S2S3S4S5γ4γ5I4I5Q1Q2Q3Q4Q5Figure 6.6100.5100.510 1 2 3 4 500.51Time0 1 2 3 4 5Time0 1 2 3 4 5Time111111 111111State occupancy probabilitiesS1S1S1S2S2S2S3S3S4x1x1x1x2x2x2x3x3x4Figure 6.6240.42420.100.51036912gγ = {0,0,0,15}01230 1 2 3 4 5gTimeγ = {0,0,15,0}0 1 2 3 4 5Time0 1 2 3 4 5TimeS1S2S3S4x1x2x3x4400 800 1200 1600 2000Residue position43210−1−2−3−4HydrophobicityI II III IVS1 S6Figure 6.68SS1SS2COOϒNH2+I II III IVIntracellularExtracellularTTXhTTXTTX TTXS1S2S3S4++++S5SS1SS2S1S2S3S4++++S5S6SS1SS2S1S2S3S4++++S5S6SS1SS2S1S2S3S4++++S5S6S6Figure 6.69S1 S4S2 S3S6S5SS1SS2S2S1S3S4S5 S6SS1SS2S1S2S3S4S5S6SS1SS2S1S2S3S4S5S6SS1SS2IIIIIIIVFigure 6.70Y. Jiang, A. Lee, J. Chen, V. Ruta, M. Cadene, B. Chalt, and R. MacKinnon (2003),Nature 423:33-41.Y. Jiang, A. Lee, J. Chen, V. Ruta, M. Cadene, B. Chalt, and R. MacKinnon (2003),Nature
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