IntroductionBioengineering 6000 CV Physiology Systems Physiology I:Cardiovascular, Respiratory, and Renal SystemsBioengineering 6000 CV PhysiologyIntroductionQuote of the Day (Week, or Semester)“A mediocre person tells. A good person explains. A superior person demonstrates. A great person inspires others to see for themselves."Harvey MackayHarvey Mackay (born 1932 in Saint Paul, Minnesota) is a businessman and columnist. Mackay is perhaps best known as the author of five business bestsellers, including Swim With the Sharks (Without Being Eaten Alive), Beware the Naked Man Who Offers You His Shirt and Dig Your Well Before You're Thirsty. He is a nationally syndicated columnist, and one of America's most popular business speakers. He is also founder, Chairman and CEO of Mackay Envelope Corporation, whose story he tells in anecdotes sprinkled throughout his books.Bioengineering 6000 CV PhysiologyIntroductionOrganization• Instructors: Rob MacLeod ([email protected])• TA: Andrew Miller ([email protected])• Web page: http://www.sci.utah.edu/~macleod/be6000• Canvas page:https://utah.instructure.com/courses/269693Bioengineering 6000 CV PhysiologyIntroductionWeb SiteBioengineering 6000 CV PhysiologyIntroductionCanvasBioengineering 6000 CV PhysiologyIntroductionLecture Syllabus• Cardiac electrophysiology/mechanics– Membrane and cellular structure/function– Action potentials– Cardiac tissue and bioelectricity– Cardiac mechanics, regulation• Cardiovascular structure/function– Vascular system– Hemodynamics, transport, regulation• Respiration– Gases and gas transport– Ventilation– Regulation• Renal function– Osmotic regulation– Renal transport– RegulationBioengineering 6000 CV PhysiologyIntroductionLab Syllabus• Sessions:– Dissection of CV system (bovine heart)– Regulation of cardiac function (frog)– Exercise and blood pressure – ECG – Pulmonary function– Simulation • TA: Andrew Miller ([email protected])Bioengineering 6000 CV PhysiologyIntroductionScheduleBioengineering 6000 CV PhysiologyIntroductionResource Material• Class web page : – www.sci.utah.edu/~macleod/be6000• Text: Eckert Animal Physiology, Randall, Burggren, & French• Notes: available before most lectures on the web site in pdf format.• Study topic list: prepared before each major test• Additional references (see web site):– Human Physiology: An Integrated Approach by Silverthorn– Physiology by Berne and Levy; – Mathematical Physiology by Keener and Sneyd– Cardiovascular Physiology by Mohrman and Heller.Bioengineering 6000 CV PhysiologyIntroductionLabs• Goals:– Put theory into practice– Get exposure to real biological data– Encourage sound analysis and interpretation– Develop/improve writing and organizational skills– Explore Design of Experiments • Guidelines:– Generally two lab days per lab (Friday/Monday, Friday/Tuesday, Wed/Friday)– Sign up for the lab Doodle Poll: see web site– Review lab instructions and associated web sites for Friday– Start of lab time: 12:00 on Friday, 1:00 pm MondayBioengineering 6000 CV PhysiologyIntroductionLab Logistics• Lab time: Friday at 12:00 and Monday at 1:00 PM• First lab: Friday, Jan 10 (this week!!)• Lab materials– Camera (one per team)– Tolerant, comfortable clothesBioengineering 6000 CV PhysiologyIntroductionLab Reports• Writing/presentation is important!• Format varies with the lab• Emphasis on results and discussion• Requirement of clear, logical, concise scientific writing• Plentiful feedback (our job)• Resubmissions allowed (on first two labs)Bioengineering 6000 CV PhysiologyIntroductionMy Expectations• Already possess a basic understanding of human physiology, e.g., Human Physiology: in Integrated Approach, by Silverthorn• Already have a working knowledge of MATLAB• Immediately check Canvas: see web site for instructions• Already have previous experience with writing lab reports• Plan to read the text (during the semester)• Plan to read some literature• Ask questions and participateStudents should:Bioengineering 6000 CV PhysiologyIntroductionOur Deliverables• Intermediate level coverage of cardiovascular physiology• Generalized approach to physiological systems• Lab experiences that integrate class material• Design of experiments• Feedback and a chance to act on that feedback • Flexible syllabus based on class interest• Answers to the Why Should We Care? question at any time• Experiment with peer learning• Accessibility: after class and by email are bestWe will offer:Bioengineering 6000 CV PhysiologyIntroductionGrading• Exams: 3 * 15% = 45% of total grade– Types of questions • True/false with explanation• Describe a mechanism• Explain an observation• Interpret data• Labs: 30%– 6 labs with written reports,• Semester project: 20%– Written exploration of extreme physiology• Homework: 5%– 2-3 homework assignments– Simulations, calculationsIntroductionBioengineering 6000 CV PhysiologyDeath Zone VideoMotivation and background for semester projectBioengineering 6000 CV PhysiologyIntroductionComments from VideoStructureContentApproachMessageBioengineering 6000 CV PhysiologyIntroductionLab SchedulingBioengineering 6000 CV PhysiologyIntroductionLab SchedulingDecisionFriday Lab: 2:00 Monday Lab: 1:00Bioengineering 6000 CV PhysiologyIntroductionLab SchedulingHeather’s reply re BIOEN 4202 Friday sessions:“I haven’t had any students in the past approach me with anything I couldn’t work around, so I don’t anticipate it being an issue the students can’t manage.”Bioengineering 6000 CV PhysiologyIntroductionLab Planning and PracticeGoalsBefore During AfterLogisticsData AcquisitionData ProcessingCareful ExecutionCleanupBioengineering 6000 CV PhysiologyIntroductionExcellent Photo ExampleBioengineering 6000 CV PhysiologyIntroductionAnd AnotherBioengineering 6000 CV PhysiologyIntroductionCow Specific InformationIntroductionBioengineering 6000 CV PhysiologyMeanwhile, Back in the Classroom...Bioengineering 6000 CV PhysiologyIntroductionLearning Approach: Problem SolvingBioengineering 6000 CV PhysiologyIntroductionLearning Approach: MotivationBy Force?Bioengineering 6000 CV PhysiologyIntroductionDon’t memorizeAsk Good Questions!So what are some good questions?Bioengineering 6000 CV PhysiologyIntroductionLearning Approach:Finding Good QuestionsAnn Improb.Res., annual swimsuit issue, 4(2)